Vascular dementia trials.
39 Vascular dementia trials, curated for APOE4 carriers — 28 of them recruiting. Each one translated into plain English, with our read on what it means for an APOE4 carrier.
- Observational only, China-based populationNCT03653156China Cognition and Aging Study
This is a large observational study based in China, not a drug or treatment trial. Researchers are building a national database by following thousands of…
- Unrelated to APOE4 or Alzheimer'sNCT03047369The Myelin Disorders Biorepository Project
This is a biorepository project, not a treatment trial. Researchers are collecting medical records and biological samples (like blood or tissue) from people…
- Observational study, genotype not a factorNCT03403257Brain Attack Surveillance in Corpus Christi--Cognitive (BASIC-Cognitive)
This is an observational study, not a treatment trial. Researchers are tracking how often cognitive impairment and dementia occur in Mexican American adults…
- Vascular dementia only, not APOE4-specificNCT03804229Efficacy and Safety of Butylphthalide Soft Capsule for the Treatment of Vascular Dementia
This Phase 3 trial is testing whether Butylphthalide soft capsule — a drug already used in China for stroke-related brain injury — can improve thinking, daily…
- Monitoring tool, genotype not relevantNCT04114994Longitudinal Cognitive Assessment by BoCA
This study is testing a self-administered online cognitive test called BoCA — the Boston Cognitive Assessment. Researchers want to see how well it tracks…
- Unrelated to APOE4 genotypeNCT04310098CADASIL Registry Study
This is a registry study — not a drug trial — tracking people with CADASIL, a rare inherited condition that damages small blood vessels in the brain and causes…
- Lifestyle study, genotype not requiredNCT04337255Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients Patients
This trial tests whether following the MIND diet for two to three years after a stroke slows cognitive decline compared to standard post-stroke dietary care.…
- Observational only, genotype not specifiedNCT04916210Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
The DISCOVERY study is an observational study — no drug or treatment is being tested. Researchers are following stroke survivors over time, collecting…
- Observational only, genotype not consideredNCT05023564PUMCH Dementia Longitudinal Cohort Study
This is an observational cohort study based at a major Chinese hospital. Researchers are following elderly Chinese patients who already have a confirmed…
- Not relevant to APOE4 carriersNCT05473637Taiwan Associated Genetic and Nongenetic Small Vessel Disease
This study is enrolling people who show signs of cerebral small vessel disease, a condition where tiny blood vessels in the brain are damaged, sometimes…
- CAA enrolling, genotype not stratifiedNCT05734378Prognosis of Cerebral Small Vessel Disease
This is an observational study, not a drug trial. Researchers are following people already diagnosed with cerebral small vessel disease to track what happens…
- Unrelated to APOE4 genotypeNCT05755997CERebrolysin In CADASIL
This trial is testing Cerebrolysin — an intravenous drug derived from pig brain proteins, thought to support nerve cell health — against a saltwater placebo in…
- Observational stroke study, genotype not relevantNCT05885295The Imperial Comprehensive Cognitive Assessment in Cerebrovascular Disease (IC3)
This study is testing a new digital cognitive assessment tool called IC3, designed specifically for stroke survivors. Researchers want to know whether it can…
- Lifestyle study, genotype not requiredNCT05886114A Multi-domain Lifestyle Intervention Among Aged Community-residents in Zhejiang, China
This trial is testing whether a structured program combining exercise, nutrition, cognitive training, social activities, and vascular risk management can slow…
- Observational imaging, genotype not specifiedNCT06010511WHIte MAtter Hyperintensity Shape and Glymphatics
This observational study is using both standard 3T and ultra-high-field 7T MRI scans to examine white matter lesions in the brains of older adults with…
- Not relevant to APOE4 carriersNCT06079216Making Connections Thru Music
This trial tests whether trained volunteers can lead music and conversation sessions for people living with dementia in long-term care facilities just as…
- Observational only, genotype not specifiedNCT06120361The Swedish BioFINDER - Primary Care Study
This Swedish study is testing whether blood-based biomarkers and cognitive assessments can accurately detect Alzheimer's disease and other forms of cognitive…
- Observational study, genotype not specifiedNCT06122415The Swedish BioFINDER - Memory Clinic Study
This Swedish study is testing whether new blood tests can replace spinal fluid tests for diagnosing memory and dementia conditions. Researchers are comparing…
- Unrelated to APOE4 genotypeNCT06148051AusCADASIL: An Australian Cohort of CADASIL
This study is building a long-term registry of Australians with CADASIL, a rare inherited condition that damages small blood vessels in the brain. Researchers…
- Records study, no APOE4 relevanceNCT06209515Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study
This is not a clinical treatment trial. It is a Finnish records-based research study examining whether people later diagnosed with a neurodegenerative disease…
- Vascular focus, genotype not relevantNCT06289569Home Tele Rehabilitation Therapy for Vascular Dementia
This trial tests whether physical rehabilitation delivered via video or remote technology at home is practical and reduces caregiver burden for stroke…
- Open to carriers, genotype not relevantNCT06298474The BRAIN App (Phase 2 SBIR)
This trial is testing a tablet-based app called BRAIN that uses AI to deliver personalized Cognitive Stimulation Therapy to people living with dementia in…
- Lifestyle study, genotype not requiredNCT06378372How Does Pianistic Musical Training Influence the Development of Alzheimer's Disease?
This trial is testing whether learning to play the piano can influence how Alzheimer's disease progresses. Participants with early to moderate cognitive…
- Closed cohort, genotype not relevantNCT06416371Retinal Vessel Leakage in Cerebral Small Vessel Disease
This observational study is testing whether blood vessels in the retina (the back of the eye) leak in people who have cerebral small vessel disease — a…
- General dementia trial, genotype not consideredNCT06514066Cannabidiol's Role in Dementia Management
This Phase 2 trial in Malaysia is testing whether cannabidiol (CBD) oil can improve cognitive function, daily living, mood, and quality of life in people…
- Open to carriers, not 4-specificNCT06718686Rifaximin SSD in Dementia Trial
This trial is testing a new low-dose formulation of rifaximin, an antibiotic that stays in the gut rather than entering the bloodstream, to see whether it can…
- Non-drug trial, genotype not consideredNCT06733714Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults
This trial combines two non-drug approaches — a brain-stimulation device called tACS, which delivers mild electrical currents to the scalp, and a computerized…
- Not relevant to APOE4 carriersNCT06859658Development and Validation of a Functional MRI Biomarker of Cerebral Small Vessel Dysfunction in CADASIL
This study is testing whether a specific type of brain MRI scan can reliably detect early blood vessel dysfunction in people with CADASIL, a rare inherited…
- Open to carriers, not 4-specificNCT06862557Pulsed Electromagnetic Field Treatment With Dementia Patients
This trial is testing a wearable device that emits pulsed electromagnetic fields, used at home three times a day for 120 days, in people with mild to moderate…
- Behavioral study, genotype not consideredNCT06898931Language Intervention Training for Cognitive Protection in High-risk Cardio-Cerebrovascular Elderly Population
This trial is testing whether a dialect-switching training program can protect cognitive function in older adults who are at high risk for stroke. Participants…
- Observational only, genotype not studiedNCT06903078A Study That Collects Participant Data and Biospecimens to Analyze Pathogenic Exosomes That Mediate Increased Vascular Dementia Risk in Individuals With Herpes Zoster.
This observational study is collecting blood samples and health data from people who have active shingles to see whether shingles raises the risk of blood…
- Unrelated to APOE4 riskNCT06935578RAre, But Not aLone: a Large Italian Network to Empower the Impervious diaGNostic Pathway of Rare cerEbrovascular Diseases (ALIGNED)
This Italian registry study is building a national network to improve diagnosis of rare inherited and acquired cerebrovascular diseases — conditions like…
- Different disease, not APOE4-relevantNCT06938100Genotype, Clinical Features and Imaging of Neuroradiological Abnormalities in CADASIL
This study is following people with CADASIL, a rare inherited disease that damages small blood vessels in the brain and is caused by mutations in the NOTCH3…
- Open to carriers, not 4-specificNCT06993207HOme-based Brain Monitoring With a GARment-EEG to Study Cognitive Decline in the Aging Population
This study is testing a wearable EEG headband kit called HOGAR, designed to monitor brain activity and sleep at home. Researchers want to know whether this…
- Vascular diagnosis required, not APOE4-focusedNCT07149038Evaluation of Cerogrin for Auricular Vagus Nerve Stimulation in Vascular Dementia or Vascular Mild Cognitive Impairment
This trial tests Cerogrin, a wearable ear device that delivers mild electrical stimulation to the vagus nerve, in people with vascular dementia or vascular…
- Observational only, genotype not a factorNCT07259499Predictors of Emergency Department Use in Frail Patients
This study is testing whether a blood marker called phosphorylated tau 181, along with signs of blood vessel damage in the brain seen on imaging, can predict…
- Unrelated genetic condition, not APOE4NCT07497867Long-term Prospective Study of Korean CADASIL Patients
This is a 10-year observational study tracking 500 Korean patients who have CADASIL, a rare inherited condition that damages blood vessels in the brain and…
- Open to carriers, not 4-specificNCT07545473Retinal Hyperspectral Imaging in Neurodegenerative Diseases
This study tests whether a special eye-scanning camera can detect signs of Alzheimer's and other brain diseases by photographing the retina using multiple…
- Not relevant to APOE4 carriersNCT07650110Biological Collection of the Rare Diseases of the Brain and Eye Vessels Cohort - 2
This is a French biobank study, not a treatment trial. Researchers are collecting blood samples and clinical data from people with rare inherited brain vessel…
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Educational, not medical advice. Trial decisions belong between you and your physician.