NCT05473637 · RECRUITING
Taiwan Associated Genetic and Nongenetic Small Vessel Disease
This study is enrolling people who show signs of cerebral small vessel disease, a condition where tiny blood vessels in the brain are damaged, sometimes causing stroke, memory problems, or movement issues. Researchers are using genetic testing and brain MRI to find out how many cases are caused by known gene mutations versus other factors, then tracking participants for at least two years. This is an observational registry, not a treatment trial.
Eligibility criteria
Inclusion Criteria: Participants must have at least one of the following symptoms/signs or history * stroke (especially small vessel occlusion type of ischaemic stroke, spontaneous ICH or young stroke) * cognitive impairment or dementia * gait disturbance * parkinsonism (especially vascular parkinsonism features) * headache (especially migraine) * positive family history of hereditary CSVD * MRI evidence of CSVD (MRI may be done for other reasons), including mild to moderate white matter hyper intensity, any lacune, or any cerebral microbleed Exclusion Criteria: * MRI evidence of CSVD due to other inflammatory, malignancy, or structural lesions * patients or family members not willing to sign informed consent
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-01-20