NCT06010511 · RECRUITING
WHIte MAtter Hyperintensity Shape and Glymphatics
This observational study is using both standard 3T and ultra-high-field 7T MRI scans to examine white matter lesions in the brains of older adults with cognitive decline or dementia. Researchers want to understand whether the shape and location of these lesions can reveal different underlying disease processes, and whether brain waste-clearance (glymphatic) system markers can help explain how dementia develops. No phase is listed — this is a research imaging study, not a drug trial.
You may qualify if
- Admitted to the memory or the geriatric clinic of the LUMC, the Alrijne Hospital Leiden or the Haga Hospital the Hague
- From 65 years of age
- Eligible for MRI
- Native-level Dutch speaker
You're excluded if
- Claustrophobia
- Contraindications for MRI such as metal implants and pacemaker
- Use of benzodiazepines
- Initiated treatment with antidepressants less than 6 weeks prior to inclusion
- Not being able to provide written informed consent (assessed by the treating physician)
- Individuals that have been declared mentally incapacitated
- Other severe neurological disease besides dementia related
- Cognitive impairment due to known other neurological disease
- Previous brain surgery
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-04-13