Mild cognitive impairment trials.
353 Mild cognitive impairment trials, curated for APOE4 carriers — 196 of them recruiting. Each one translated into plain English, with our read on what it means for an APOE4 carrier.
- Observational only, China-based populationNCT03653156China Cognition and Aging Study
This is a large observational study based in China, not a drug or treatment trial. Researchers are building a national database by following thousands of…
- Exclusively enrolls APOE4 homozygotesNCT03887741Plasmapheresis Versus Plasma Infusion from Young APOE3 Homozygotes Into MCI APOE4 Homozygotes to Slow Disease Progression
This trial is testing whether it is safe to give plasma from young APOE3 carriers to people who are APOE4 homozygous and already showing mild cognitive…
- Directly recruits APOE4 carriersNCT04430517Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia
This early-phase trial is testing nicotinamide riboside, a form of vitamin B3, in people who already have mild cognitive impairment or mild Alzheimer's…
- Requires at least one APOE4 alleleNCT05245903Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside
This trial is testing whether a supplement called nicotinamide riboside (a form of vitamin B3) produces measurable changes in brain energy metabolism in people…
- APOE4 carriers central to studyNCT06335836The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD)
This trial is studying how social isolation and social interaction affect the brain and the risk of progressing from subjective cognitive decline to more…
- APOE4 genotyped, non-drug device trialNCT06467253Comparison of Two Non-invasive Neuromodulation Techniques as Synergistic Therapy to Cognitive Stimulation in Amnestic Mild Cognitive Impairment (aMCI)
This trial is testing two types of non-invasive brain stimulation — repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current…
- Genotype-stratified, carriers likely eligibleNCT07027072Study to Evaluate the Efficacy and Safety of KDS2010 in Patients With Alzheimer's Disease With Mild Cognitive Impairment and Mild Dementia Due to Alzheimer's Disease
This trial is testing KDS2010, an experimental oral drug taken once daily, in people who have early Alzheimer's-related memory problems — either mild cognitive…
- APOE4 4/4 carriers excludedNCT07456462Making Antibody Treatments More Effective in Early Alzheimer's Disease Using 3Tesla Magnetica Resonance
This study is testing whether advanced MRI scans and blood tests can predict how well lecanemab or donanemab are working in people with early Alzheimer's…
- Exclusively recruits APOE4 carriersNCT07516119Predicting Pre-dementia
This observational study is testing whether a multimodal prediction model — combining genetic risk scores, blood biomarkers, health record data, and wearable…
- APOE4 carriers explicitly excludedNCT07612449Percepta for Cognitive Optimization
This trial is testing a dietary supplement called Percepta, made from cat's claw bark extract and oolong tea extract, to see whether it improves cognitive…
- Exclusively recruits APOE4 carriersNCT07646054Digital Lifestyle Coaching for Alzheimer's Disease Prevention in APOE4 Carriers
This trial is testing whether a year-long digital lifestyle coaching program can improve blood-based markers linked to Alzheimer's risk. Twelve hundred…
- Open to carriers, not 4-specificNCT01532739Making Memory Better for Seniors With Mild Cognitive Impairment
This trial tests a group-based cognitive training program for people with Mild Cognitive Impairment (MCI). It focuses on everyday memory problems and pairs…
- Open to carriers, genotype not consideredNCT02525198The Cognitive Ageing Nutrition and Neurogenesis (CANN) Trial
This trial is testing a dietary supplement that combines fatty acids (like omega-3s) and flavonoids (plant-based compounds) to see whether the combination…
- Open to carriers, not 4-specificNCT02814526Exercise in Adults With Mild Memory Problems
This trial tests whether aerobic exercise (like treadmill walking) does more for brain health than stretching and balance routines in older adults with mild…
- Observational only, no treatment involvedNCT02951598A Study of Health Care Use and Costs in Participants With Early Stage Alzheimer's Disease (AD)
This study is not testing a treatment. It is an observational study tracking how people with early-stage Alzheimer's disease or MCI use health care, what that…
- Non-drug trial, genotype not consideredNCT02959502Home-Based CR and tDCS to Enhance Cognition in Persons With Mild Cognitive Impairment and Late Life Depression
This trial is testing a home-based combination of cognitive rehabilitation (structured mental exercises) and transcranial direct current stimulation (tDCS, a…
- Parkinson's trial, genotype not relevantNCT03025334tDCS on Parkinson's Disease Cognition
This trial is testing whether a non-invasive brain stimulation technique called high-definition transcranial direct current stimulation (HD-tDCS) can improve…
- Open to carriers, genotype not trackedNCT03113461MCI: CPAP Treatment of OSA (Memories2)
This trial is testing whether CPAP — the device used to treat sleep apnea — can slow the progression of memory problems in people who already have mild…
- Observational only, genotype not requiredNCT03136679Discovery of Novel Biomarkers That Will Lead to the Early Detection of Alzheimer's Disease
This study is collecting blood and urine samples from people with varying degrees of cognitive impairment to search for new biological markers that might…
- Observational only, genotype not relevantNCT03162081Medication Misuse and Dependence Among Elderly
This study is looking at how older adults use — and sometimes misuse — prescription medications, particularly drugs that can be habit-forming. Researchers are…
- Explicitly lists APOE4-positive carriersNCT03233646Retinal Imaging in Neurodegenerative Disease
This study uses non-invasive eye-imaging technology — optical coherence tomography (OCT) and wide-field retinal photography — to look for early signs of…
- Behavioral study, genotype not consideredNCT03430401Computer-based Cognitive Rehabilitation Program for Healthy Older Adults, Older People With Mild Cognitive Impairment and Mild Dementia
This trial tests a computer-based memory training program delivered via iPad. Participants learn specific strategies for encoding — or storing — memories more…
- Non-drug study, genotype not requiredNCT03444181ALzheimer and MUsic THerapy: Effects of Music Lessons on Brain Plasticity, Mood, and Quality of Life in Alzheimer Patients
This trial is testing whether a year of music lessons designed for people with Alzheimer's disease can slow brain shrinkage, improve mood, and raise quality of…
- Open to carriers, not 4-specificNCT03493178Glutathione in Mild Cognitive Impairment
This trial is testing whether two dietary supplements, glycine and N-acetylcysteine (NAC), can raise glutathione levels in people with mild cognitive…
- Open to carriers, not 4-specificNCT03507257Longitudinal Early-onset Alzheimer's Disease Study Protocol
LEADS is an observational study, not a treatment trial. Researchers are tracking how early-onset Alzheimer's and related conditions progress over time in…
- Open to carriers, not 4-specificNCT03556280Multi-Center Study of Sensory Stimulation to Improve Brain Function
This trial tests a device called the GammaSense Stimulation System, which delivers sensory stimulation at a specific brain rhythm frequency called gamma.…
- Open to carriers, not 4-specificNCT03649724The LUCINDA Trial: LeUprolide Plus Cholinesterase Inhibition to Reduce Neurological Decline in Alzheimer's
The LUCINDA Trial is testing whether leuprolide acetate, a hormone-suppressing drug already used for other conditions, can slow cognitive decline when added to…
- APOE4 genotype central to studyNCT03654911Sustainable Method for Alzheimer's Prediction
This observational study is testing whether a combination of brainwave recordings (EEG), neuropsychological testing, and APOE genotyping can reliably predict…
- Open to carriers, not 4-specificNCT03657745Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy
This trial is testing an iPad app called AlzLife that flashes light at 40 times per second (40Hz) combined with cognitive exercises. The idea is that this…
- Open to carriers, genotype not trackedNCT03665831Deep TMS for Comorbid Depression and Cognitive Impairment in Older Adults
This trial is testing whether a non-invasive brain stimulation device called deep TMS, using a specialized H1 coil aimed at the left prefrontal cortex, can…
- Lifestyle study, genotype not requiredNCT03772977The Brain Health Champion Study
This trial tests whether more frequent, personalized coaching on brain-healthy habits produces better follow-through than standard doctor advice alone.…
- Not relevant to APOE4 carriersNCT03836950rTMS to Improve Cognition in Parkinson's
This trial is testing repetitive transcranial magnetic stimulation, or rTMS, a non-invasive device that delivers magnetic pulses to the brain, to see whether…
- Observational only, genotype not specifiedNCT03851523Longitudinal Study for the Characterization of the Phases of Subjective Perception of Cognitive Decline and Mild Cognitive Impairment of Alzheimer's Disease.
This observational study tracks people over time to understand the very earliest signs of Alzheimer's disease — specifically, what happens when someone feels…
- Open to carriers, not 4-specificNCT03881579Supportive Care for Cognitively Impaired Patients and Families
This trial tests whether a year-long nurse-led palliative care program improves quality of life and reduces healthcare use for people living with dementia or…
- General planning study, not genotype-specificNCT03960476Decision Making and Implementation of Aging-in-Place/Long Term Care Plans Among Older Adults
This study is testing a website called PlanYourLifespan.org to understand how older adults make long-term care and aging-in-place decisions. Researchers want…
- Open to carriers, not 4-specificNCT04033510Acute Cognitive Changes During Atrial Fibrillation Episodes (AFCOG)
This study tests whether people with atrial fibrillation (an irregular heart rhythm) think and remember less clearly during an AF episode than when their heart…
- Explicitly targets APOE4-related conditionNCT04049643Hearing Aid and Individuals With Cognitive Disorders
This pilot study is testing whether different ways of fitting hearing aids — by an audiologist, through a support service, or as a standalone device — can help…
- Open to carriers, not 4-specificNCT04070703Tai Ji Quan and Cognitive Function in Older Adults With Mild Cognitive Impairment
This trial is testing whether a specially designed Tai Ji Quan program can improve memory and thinking skills, as well as the ability to do two things at once,…
- Open to carriers, genotype not trackedNCT04098666Metformin in Alzheimer's Dementia Prevention
This trial is testing whether extended-release metformin, a widely used diabetes drug, can slow memory decline in people who are overweight and already showing…
- Open to carriers, genotype not requiredNCT04100057Sleep Disturbance and Emotion Regulation Brain Dysfunction as Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Dementia
This trial tests whether treating insomnia with Cognitive Behavioral Therapy for Insomnia (CBT-I) reduces anxiety, depression, agitation, and other behavioral…
- Monitoring tool, genotype not relevantNCT04114994Longitudinal Cognitive Assessment by BoCA
This study is testing a self-administered online cognitive test called BoCA — the Boston Cognitive Assessment. Researchers want to see how well it tracks…
- Non-Alzheimer's focus, carriers may not qualifyNCT04120766Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging
This Phase 2 trial is testing nicorandil, a drug already used for heart conditions, to see whether it is safe and whether it affects a brain pathway linked to…
- Open to carriers, not 4-specificNCT04123314Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
This early Phase 1 pilot study is testing whether a single supervised dose of psilocybin — the active compound in psychedelic mushrooms — is safe and can ease…
- Observational study, genotype not consideredNCT04124029Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)
This observational study is not testing a treatment. It is using EEG brain scans, MRIs, blood draws, and spinal fluid samples to study whether Veterans who…
- Observational only, genotype not relevantNCT04134806Gait Analysis by Induced Disorientation in a VR Environment
This study uses a virtual reality headset to deliberately disorient participants and then measures how that disorientation affects the way they walk.…
- Open to carriers, not 4-specificNCT04148391NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's Disease or Lewy Body Dementia (Cognition, Memory, Attention, Thinking)
This trial is testing NYX-458, an experimental oral drug, against a placebo in people who have mild cognitive impairment or mild dementia caused by Parkinson's…
- Open to carriers, genotype not trackedNCT04171323The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
This trial is testing different combinations of computerized brain exercises to see which combination best helps older adults with mild cognitive impairment…
- Device study, genotype not consideredNCT04240561Characterizing Variability in Hearing Aid Outcomes in Among Older Adults With Alzheimer's Dementia
This trial is testing two different hearing aid signal processing approaches in older adults who have Alzheimer's dementia or amnestic mild cognitive…
- Open to carriers, not 4-specificNCT04262206Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
PREVENTABLE is a large Phase 4 trial testing whether atorvastatin 40 mg — a common cholesterol-lowering statin — can reduce the combined risk of death,…
- Open to carriers, genotype not requiredNCT04296565Water-based Activity to Enhance Recall in Veterans
This trial tests whether combining water-based exercise with a cognitive training program improves memory in veterans who have amnestic Mild Cognitive…
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Educational, not medical advice. Trial decisions belong between you and your physician.