NCT03772977 · ACTIVE NOT RECRUITING
The Brain Health Champion Study
This trial tests whether more frequent, personalized coaching on brain-healthy habits produces better follow-through than standard doctor advice alone. Participants receive guidance on things like exercise, diet, and sleep over six months. It is a Phase NA behavioral study, meaning it is evaluating a structured lifestyle program rather than a drug, and researchers are measuring whether the extra support actually changes what people do day to day.
You may qualify if
- Be age 60 to 79
- Existing patient at Brigham Health system with at least one prior visit with providers and plans to establish/continue longitudinal care
- Be sufficiently fluent in the English language to understand instructions and perform the cognitive and functional tests
- For neurology participants only: Have a diagnosis of Subjective Cognitive Disorder (SCD) (MMSE guideline 27-30), Mild Cognitive Impairment (MCI) due to Alzheimer disease (AD), cerebrovascular disease (CVD), or mixed-type AD/CVD (MMSE guideline 24-30), or mild dementia due to AD, CVD, or mixed-AD/CVD (MMSE guideline 20-30). In some cases, based on the clinical judgment of the treating neurologist, we may enroll a patient who falls outside of these guidelines or whose diagnosis and overall level of functioning does not perfectly correlate to their MMSE score.
- For primary care participants only: Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) dementia risk score of ≥ 6, or score of 5 plus one of the following: a history of ADRD in a first-degree relative, or type II diabetes or "pre-diabetes" spectrum (A1C level ≥ 5.7)
You're excluded if
- Be enrolled in another health behavior or non-pharmacologic intervention for a neurocognitive disorder
- Be unable to or unwilling to carry out regular physical exercise, multiple times weekly.
- Be not recommended to participate by their Internist/Primary Care Provider due to health-related concerns.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-11-21