NCT03851523 · RECRUITING
Longitudinal Study for the Characterization of the Phases of Subjective Perception of Cognitive Decline and Mild Cognitive Impairment of Alzheimer's Disease.
This observational study tracks people over time to understand the very earliest signs of Alzheimer's disease — specifically, what happens when someone feels their memory is slipping but still tests normally. No treatment is given. Researchers follow participants through stages from subjective cognitive concern to mild cognitive impairment to early dementia, measuring biomarkers and cognitive tests along the way. This is a longitudinal observation study, not a treatment trial.
You may qualify if
- Men and women between 45 and 74 years at the time of inclusion in the 45-65/FPM2012 study or older than 45 for persons who have not previously participated in 45-65/FPM2012.
- Cognitively healthy persons with SCD, as well as people with MCI and mild dementia.
- Participation of a relative to perform the subjective memory complaint and clinical interview.
You're excluded if
- Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the protocol.
- Any significant disorder that could course with cognitive impairment that is not related to AD.
- Family history of monogenic AD.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-05-31