NCT06416371 · RECRUITING
Retinal Vessel Leakage in Cerebral Small Vessel Disease
This observational study is testing whether blood vessels in the retina (the back of the eye) leak in people who have cerebral small vessel disease — a condition that damages tiny blood vessels in the brain and raises dementia risk. Researchers want to know if retinal leakage severity tracks with brain disease severity. There is no drug or treatment involved; participants receive an eye imaging test using an injected fluorescent dye. Details on phase are unspecified.
You may qualify if
- Membership in the Mild Stroke Study 3 cohort
- Contrast enhanced MRI within 12 months
- Clear optical media in both eyes, as assessed by study investigator
- Best corrected visual acuity (near vision) ≥N36
You're excluded if
- Any condition known to cause retinal leakage (i.e., worse than background diabetic retinopathy, retinal vein occlusion, active uveitis, wet age-related macular degeneration, malignant hypertension)
- Previous treatment for retinal leakage (retinal laser, intravitreal anti-VEGF)
- Recent eye surgery
- Shallow anterior chambers as assessed by torch test
- Pregnancy, renal failure
- Severe dementia
- Known allergy to fluorescein
- History of allergy such as food or drug induced urticaria or history of bronchial asthma
- Any other severe or acute medical or psychiatric conditions
- Inability to give informed consent
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-03-04