Trials in Alabama.
24 APOE4-relevant Alzheimer’s trials run in Alabama — 13 of them recruiting. Each one translated into plain English, with our read on what it means for an APOE4 carrier.
- Carriers enrolled, but higher ARIA riskNCT01767311A Study to Evaluate Safety, Tolerability, and Efficacy of Lecanemab in Subjects With Early Alzheimer's Disease
This Phase 2 trial tested lecanemab, an anti-amyloid antibody given by infusion, in people with early Alzheimer's disease — either mild cognitive impairment or…
- APOE4 carriers explicitly welcomedNCT04468659AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid
This Phase 3 trial is testing lecanemab, an anti-amyloid antibody drug, in people who are cognitively normal but have early amyloid buildup in their brains —…
- Amyloid-focused, drug did not succeedNCT02008357Clinical Trial of Solanezumab for Older Individuals Who May be at Risk for Memory Loss
This Phase 3 trial tested solanezumab, an antibody drug given by IV infusion, in cognitively normal older adults who already had amyloid buildup in their…
- Heart trial, genotype not relevantNCT02884206Efficacy and Safety of LCZ696 Compared to Valsartan on Cognitive Function in Patients With Chronic Heart Failure and Preserved Ejection Fraction
This Phase 3 trial tested whether LCZ696 (sacubitril/valsartan, sold as Entresto) protects cognitive function better than valsartan alone in people with a…
- Open to carriers, not 4-specificNCT04262206Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
PREVENTABLE is a large Phase 4 trial testing whether atorvastatin 40 mg — a common cholesterol-lowering statin — can reduce the combined risk of death,…
- FTLD-focused, not APOE4-relevantNCT04363684ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
This is a large North American research registry and natural history study tracking people with frontotemporal lobar degeneration (FTLD) and related conditions…
- Not relevant to at-risk carriersNCT04829500Effectiveness and Implementation of Montessori Approaches in Person-Centered Care Within VA
This trial is testing a staff training program called MAP-VA at eight VA long-term care facilities. The program teaches employees Montessori-based,…
- Caregiver support, genotype irrelevantNCT05098652Coaching Dementia Caregivers to Master Care-Resistant Behavior
This trial is testing a behavioral coaching program called CuRB-IT, designed to help family caregivers manage moments when a person with dementia resists or…
- No relevance to APOE4 carriersNCT05189769Reducing Racism and Discrimination in Schools: Comprehensive Prevention Services
This trial tests two school-based behavioral programs — ReACT, a school-wide anti-racism intervention, and Coping Power+, a targeted program for at-risk 7th…
- Open to carriers, not 4-specificNCT05511363A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)
This Phase 3 trial is testing KarXT, an oral drug, to see whether it prevents the return of psychosis symptoms — hallucinations and delusions — in people who…
- Familial mutation only, not APOE4NCT05552157A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
This Phase 2 trial is testing remternetug, an anti-amyloid antibody given by injection, in people who carry a rare genetic mutation (in APP, PSEN1, or PSEN2)…
- Not relevant to APOE4 or Alzheimer'sNCT05686551GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease
This trial is testing tominersen, a drug injected into the spinal fluid, against a placebo in people with prodromal or early Huntington's Disease. The goal is…
- Observational only, not APOE4 relevantNCT05927974Investigating Dynamic Interactions in Distributed Cognitive Control Networks
This study records brain activity in epilepsy patients who are already having brain electrodes implanted for seizure monitoring. Researchers want to understand…
- Late-stage AD only, genotype not relevantNCT05980949Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)
This trial is testing whether KarXT, a drug targeting certain brain receptors, is safe to take for up to a year in people who already have Alzheimer's-related…
- Genotype not considered, TBI focusNCT06217575Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans
This pilot study is testing whether EEG-guided alpha neurofeedback training and visual attention exercises can improve processing speed and daily functioning…
- Caregiver study, genotype not relevantNCT06475534The Nuestros Días ("Our Days") Study
This observational study tracks the mental health and well-being of Hispanic and Latino caregivers who look after a family member with memory problems or…
- Unrelated to APOE4 or Alzheimer'sNCT06667414Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers
This study is mapping specific genetic markers called SNPs in people who carry the Huntington's disease gene mutation. Participants give a blood sample and…
- HIV-specific trial, genotype not relevantNCT06705478Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV
This Phase 2 trial is comparing two medications — pramipexole (a dopamine-targeting drug used in Parkinson's and restless legs) and escitalopram (a common…
- Open to carriers, not 4-specificNCT06808984Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease
This trial tests BMS-986368, an experimental drug that works on the body's endocannabinoid system, to see whether it reduces agitation in people who already…
- Lifestyle study, genotype not requiredNCT07146412Impact of a Multimodal Lifestyle Intervention on Dementia Risk Factors and Attitude Related to Dementia Risk: A Logistical Pilot Study
This trial is testing a multimodal lifestyle intervention — combining multiple lifestyle changes at once — to see whether it can reduce dementia risk factors…
- Carriers tracked, ARIA risk significantNCT07169578A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
This trial is testing trontinemab, an anti-amyloid antibody drug, against a placebo in people with early Alzheimer's disease — specifically those at the MCI or…
- Gateway study, genotype not specifiedNCT07177352Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
This is not a treatment trial. It is a pre-screening study run by Roche to figure out who might qualify for their future Alzheimer's disease trials.…
- General aging study, genotype not addressedNCT07224347Aspirin in Reducing Events in the Elderly-Extension (ASPREE-XT)
ASPREE-XT is following older adults who were previously in the ASPREE aspirin trial to see what happens after they stopped taking aspirin. Researchers are…
- Relevant question, genotype not requiredNCT07546409Effects of Exogenous Ketones on Cognitive Function in Older Adults With Prediabetes?
This trial is testing whether a ketone supplement (a drink that gives the brain an alternative fuel source) can temporarily improve thinking speed and brain…
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Educational, not medical advice. Trial decisions belong between you and your physician.