NCT07546409 · ACTIVE NOT RECRUITING
Effects of Exogenous Ketones on Cognitive Function in Older Adults With Prediabetes?
This trial is testing whether a ketone supplement (a drink that gives the brain an alternative fuel source) can temporarily improve thinking speed and brain energy use in older adults with prediabetes. It compares them to adults with normal blood sugar. This is a Phase NA study, meaning it is an exploratory investigation — gathering early evidence, not a proven or approved treatment.
Eligibility criteria
Inclusion Criteria: * Age 60 to 75 years * Able to provide written informed consent * Fluent in English * No diagnosed cognitive impairment or dementia Classified as either: * Prediabetes (based on American Diabetes Association criteria), or Normal glucose regulation (control group) * Medically stable and cleared to undergo positron emission tomography and magnetic resonance imaging * Willing to comply with study procedures, including metabolic testing, supplement ingestion, and neuroimaging Exclusion Criteria: * Diagnosis of mild cognitive impairment, dementia, or other neurodegenerative disorder * Diagnosis of type 1 diabetes or type 2 diabetes * Use of glucose-lowering medications (e.g., insulin, metformin, glucagon-like peptide-1 receptor agonists) * History of major neurological disorder (e.g., stroke, traumatic brain injury with loss of consciousness >30 minutes, epilepsy, multiple sclerosis) * Major psychiatric disorder not stable on treatment * Uncontrolled hypertension or significant cardiovascular disease * Severe renal, hepatic, or gastrointestinal disease that may affect supplement metabolism * Contraindications to magnetic resonance imaging (e.g., non-compatible implanted devices, severe claustrophobia)
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-04-22