NCT07146412 · RECRUITING
Impact of a Multimodal Lifestyle Intervention on Dementia Risk Factors and Attitude Related to Dementia Risk: A Logistical Pilot Study
This trial is testing a multimodal lifestyle intervention — combining multiple lifestyle changes at once — to see whether it can reduce dementia risk factors in cognitively healthy older adults who have a family history of dementia. Researchers also want to understand how people feel about learning their personal risk. This is a Phase NA pilot study, meaning it is a small early-stage logistical test to work out the methods before a larger trial.
You may qualify if
- Adults 65-75 years of age at enrollment with at least one self-reported 1st-degree relative who had or has any kind of dementia
- Montreal Cognitive Assessment (MoCA) score > 24 at initial enrollment
- Able and willing to comprehend and sign the informed consent document
- Able and willing to perform required physical performance tests
- Able and willing to provide the study's minimum samples
- Able and willing to conduct the study's minimum procedures
- Able and willing to complete surveys, cognitive assessments, and questionnaires in English only
- Has or has ready access to a PC, tablet, or smartphone with an internet connection required for procedures that they consent to
You're excluded if
- A diagnosis of cognitive impairment of any kind, including Alzheimer's disease, mild cognitive impairment, or any other diagnosis of dementia
- If a subject is found to have cognitive impairment at initial enrollment (Montreal Cognitive Assessment (MoCA) score\<25), they will be excluded from the study
- Self-reported pregnancy
- Children under 19 years of age
- Individuals not fluent in written and spoken English
- Self-reported chronic or end-stage disease that would interfere with their participation in the study
- Hospitalization for any reason in the past 3 months
- Severe hearing and visual impairment that would interfere with the ability to complete study measures
- Any other vulnerable subject at the time of enrollment as specified above
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-08-28