NCT07600034 · NOT YET RECRUITING
Optimising Exercise to Improve Physical and Cognitive Frailty in Mild Cognitive Impairment
This trial is testing whether cycling or strength training does more to slow cognitive and physical decline in people who already have mild cognitive impairment. Participants spend 12 weeks on one type of exercise, then researchers measure brain blood flow, memory, balance, and walking ability to see what changed. It is a Phase NA trial, meaning it is a practical comparison study rather than an early drug-safety test.
You may qualify if
- males and females aged 60 until 85
- living in the community,
- confirmed diagnosis of MCI
- able to walk without assistance for at least two minutes,
- able to participate in exercise intervention screened by a physician based on ACSM guidelines
You're excluded if
- uncertain diagnosis of MCI,
- did not screen for ability to participate in exercise intervention,
- presence of other neurological, psychiatric, or cognitive impairment disorders,
- seriously ill, presence of Hepatitis B or C, cancer, and patients on immunosuppressant drugs,
- type 2 diabetes mellitus,
- uncontrolled hypertension or hypotension (systolic blood pressure >160 mm Hg and/or diastolic blood pressure >100 mm Hg at rest),
- unstable cardiac, renal, lung, liver, or other severe chronic disease,
- history of myocardial infarction and/or stroke within previous year,
- vision/hearing disorder,
- musculoskeletal disorders that affect physical function such as osteoporosis, severe knee osteoarthritis, and degenerative spinal condition,
- presence of any major psychiatric disorder (a clinical diagnosis of major depressive disorder, bipolar or schizophrenia)
- history of vitamin B12 deficiency or hypothyroidism (stable treatment for at least 3 months is allowed)
- serious or non-healing wound, ulcer, or bone fracture
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-05-20