NCT07448909 · NOT YET RECRUITING
Cognitive-Frailty Gait Biomechanics for Early Dementia Detection
This study is comparing how people with mild cognitive impairment walk, move, and score on a blood marker called BDNF — a protein linked to brain health — versus healthy older adults. It is an observational study, not a treatment trial, meaning no drug or therapy is being tested. Participants complete one session of physical measurements, a walking assessment, and a blood draw. Details on phase are not provided, as this is a data-collection study, not a clinical drug trial.
Eligibility criteria
Inclusion Criteria: * Older adults aged 50 years and above * Able to ambulate independently without the use of walking aids * Must be able to understand instructions, communicate effectively * Free from any acute or unstable medical conditions at the time of assessment. Healthy older adults group: -No history or symptoms of cognitive impairments and have normal cognitive screening results. Mild Cognitive Impairment (MCI) group: -Must fulfill established diagnostic criteria for MCI, showing measurable cognitive decline without significant functional impairment and without a diagnosis of dementia. Exclusion Criteria: * Present with any diagnosed neurological disorder such as stroke or Parkinson's disease * History of psychiatric illness, including major depressive disorder. * Individuals with uncontrolled cardiovascular, metabolic, or endocrine conditions * Have significant visual, auditory, or musculoskeletal impairments that may influence gait performance * Currently taking medications known to affect cognitive or motor function * Unable to provide written informed consent
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-03-04