NCT07411365 · NOT YET RECRUITING
Dual-task Cognitive-motor Telerehabilitation in Persons With PD-MCI
This trial tests whether a home-based dual-task training program — pedaling a stationary bike while simultaneously doing digital cognitive exercises on a tablet — can protect everyday functioning and thinking skills in people who have both Parkinson's disease and mild cognitive impairment. It is a Phase NA randomized controlled trial, meaning it is a structured behavioral study comparing two exercise approaches rather than testing a drug, and results are not yet established.
You may qualify if
- PD diagnosis confirmed by a neurologist
- PD diagnosis at least for one year
- Age between 51-80 years
- German as their mother tongue
- Diagnosis of PD-MCI according to the Level II criteria of the Movement Disorder Society
- Cognitive ADL impairment as defined by the FAQ quotient
- An informant who has given consent to provide information about the participant's activities of daily living (ADLs) and who lives in the participant's home.
- Access to a WIFI Network at home
- Unimpaired or corrected vision and hearing
- Appropriate text comprehension and reading ability
- Ability to communicate well with the investigator, to understand and comply with the requirements of the study
- Provide written informed consent to participate in the study and understand the right to withdraw consent at any time without prejudice to future medical care
You're excluded if
- Diagnosis of PDD
- Intake of anti-dementia drugs
- Deep brain stimulation
- History of brain disease other than PD (e.g. head trauma, stroke, encephalitis) also including muscular diseases (e.g. myestenia gravis or myopathy)
- Pre-existing condition that limits limb movement (e.g. muscular injuries, knee and hip disorders
- severe cardiovascular diseases with heart failure
- severe respiratory diseases (e.g. asthma and lung disease)
- severe other accompanying illnesses with impairment of lung function
- renal insufficiency
- acute stage of infectious disease
- acute stage of cancer
- other disease with pronounced physical weakness
- History of brain disease other than PD, e.g., head trauma, stroke, encephalitis
- Alcohol, medication, or drug dependency or abuse (except for nicotine)
- Signs of severe depression indicated by either the 15 item version Geriatric Depression Scale (≥ 5 points)
- Acute psychosis
- Any disability or issues that may prevent the subject from completing the informed consent form or other study requirements
- Other neurodegenerative disease which renders the subject unable to communicate well with the investigator or to understand and comply with the requirements of the study
- Participation in any clinical investigation of a new compound or therapy within 4 weeks prior to baseline visit, and any other limitation of participation based on local regulations
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-02-19