NCT07402356 · RECRUITING
VR Pupillometry in Cognitive Impairment
This study is testing whether a VR headset that tracks pupil responses can detect early signs of cognitive decline. Researchers will compare pupil behavior during memory and attention tasks across four groups: Alzheimer's disease, mild cognitive impairment, depression with cognitive symptoms, and healthy adults. Participants are followed over six months. This is an observational study, not a drug trial, so it is testing a diagnostic tool, not a treatment.
You may qualify if
- Written informed consent.
- Age 18-80 years.
- Ability to read and understand German.
- For patient cohorts: suspected or confirmed diagnosis of AD/MCI/depressive disorder with cognitive impairment according to clinical assessment and routine documentation.
You're excluded if
- Acute suicidality (e.g. BDI suicidality item > 1).
- Change of psychotropic medication within the last 4 weeks.
- Lifetime psychotic disorder (ICD-10 F20-29).
- Lack of capacity to consent.
- Lifetime bipolar disorder (ICD-10 F31).
- Acute substance abuse or harmful use of alcohol or other psychoactive substances.
- Parkinson's syndrome (ICD-10 G20).
- Multiple sclerosis (ICD-10 G35).
- Stroke within the last 12 months.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-02-17