NCT07334392 · RECRUITING

Impact of a Multicomponent Exercise Program on Cognitive and Functional Outcomes in Patients With Mild Cognitive Impairment

This trial is testing whether a structured exercise program focused on dual-task training — doing a mental task while moving, like counting while walking — improves balance, gait, and cognition in people with mild cognitive impairment (MCI). Participants exercise twice a week for three months. This is a Phase NA randomized trial, meaning it is measuring effectiveness of a non-drug approach rather than testing a new medication for safety or approval.

You may qualify if

  • individuals > 50 years old
  • people with confirmed cognitive impairment, as evidenced by values within normal limits on the Montreal Cognitive Assessment test (MOCA ) >20
  • stable medication in the last month
  • independent walking

You're excluded if

  • people with dementia
  • people suffering from chronic mental illness (e.g. schizophrenia, bipolar disorder)
  • people suffering from a neurological disorder or injuries (e.g. multiple sclerosis, Parkinson's, traumatic brain injury)
  • people with clinical depression (as determined by the Neuropsychiatric Inventory (NPI) assessment and medical diagnosis)
  • people who have had recent surgery
  • people with insufficient knowledge of the Greek language

The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.

Eligibility criteria as of 2026-01-12

View full record on ClinicalTrials.gov

All APOE4 clinical trials