NCT07248709 · RECRUITING
Comparison of High-Intensity Interval Training and Moderate-Intensity Continuous Training in Mild Cognitive Impairment
This trial compares two exercise programs in adults with Mild Cognitive Impairment: high-intensity interval training versus steady moderate-intensity exercise. Researchers are measuring effects on both cognitive function and physical fitness over eight weeks, with a follow-up at twelve weeks. It is a Phase NA trial, meaning it is comparing two established approaches rather than testing an experimental drug — the question is which exercise style works better, not whether exercise works at all.
You may qualify if
- older adults who had been diagnosed with MCI according to Peterson's criteria [Montreal Cognitive Assessment (MoCA) score \<26 for those with 12 years or more of education and \<25 for those with less than 12 years of education; activity of daily living scale ≤23; no clinical diagnosis of dementia]
- older adults who are physically normal (the six-item Katz Activities of Daily Living Scale should all be evaluated as "independent")
You're excluded if
- Participants who have medical problems or co-morbidities that interdict their participation in the study.
- Unable to walk without an assistive device
- Diagnosed with neurodegenerative diseases such as Alzheimer's disease
- Having regular exercise habits (defined as exercise for ≥150 min per week).
- Participating in other ongoing intervention study
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-12-30