NCT07225400 · NOT YET RECRUITING
Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment
This trial is testing whether people with mild cognitive impairment can use a virtual reality maze as a brain-training tool for spatial navigation. Participants walk through VR mazes while wearing EEG sensors to track brain activity changes over four months of sessions. This is a Phase NA feasibility study, meaning researchers are checking whether the approach is practical and measurable before committing to a larger test.
You may qualify if
- Age 65 and older with amnestic mild cognitive impairment (aMCI);
- Can speak English;
- Agrees to MoBI recording;
- Normal or corrected-to-normal vision/audition;
- Able to walk unassisted for 10 minutes;
- Plan to be in the area for next year
You're excluded if
- Dementia (Memory Impairment/AD8 screen);
- Medical conditions that affect participation such as vertigo and neck pain;
- Hospitalization in the past six months or plans for surgery affecting participation in the next four months;
- Mobility limitations solely due to musculoskeletal limitation or pain;
- Terminal illness with life expectancy less than 12 months;
- Presence of clinical disorders that overtly alter attention like delirium;
- Active psychoses or psychiatric symptoms;
- Living in nursing home;
- Participation in intervention trial;
- Standard contraindications to EEG including seizure medication, epilepsy, stroke, traumatic brain injury;
- Pregnant women
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-05-22