NCT06999434 · Phase 1 · RECRUITING
Exploring the Utility of [18F]3F4AP for Demyelination Imaging
This trial tests a new PET scan radiotracer called [18F]3F4AP, which is designed to image myelin — the protective coating on nerve fibers. Researchers want to see how the tracer moves through the body in healthy people and in people with conditions like MCI, Alzheimer's, MS, or spinal cord injury. This is a Phase 1 trial, meaning the focus is on basic safety and how the body handles the tracer, not on proving any treatment works.
Eligibility criteria
Inclusion: 1. Male and Female subjects must be ≥18 and \<90 years of age; 2. Able to understand and provide informed consent prior to study procedures 3. Must be in good health Exclusion: 1. Less than 18 years of age; 2. Pregnant or breastfeeding; 3. Any significant systemic illness or unstable medical condition; 4. Pre-existing medical conditions or claustrophobic reactions; 5. Research-related radiation exposure exceeds current PET Center guidelines (i.e. 50 mSv in the prior 12 months); 6. History of a bleeding disorder or are currently taking anticoagulants.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-05-31