NCT06992726 · Phase 4 · NOT YET RECRUITING
Improvement of Fish Oil in Obesity With Mild Cognitive Impairment
This trial is testing whether daily fish oil capsules (containing omega-3 fatty acids) can improve cognitive function in people who have both obesity and mild cognitive impairment. Researchers will track memory and thinking, gut bacteria, inflammation markers, and body composition over 12 months. This is a Phase 4 trial, meaning fish oil is already approved and in use — this study is asking whether it works for this specific group.
You may qualify if
- Meet the diagnostic criteria of obesity and MCI;
- Age between 35 and 80 years old;
- No dieting or stop dieting in the last 3 months, no fish oil supplements, or willing to stop self-administration of fish oil 3 months before the intervention;
- Voluntarily participate in the program with informed consent, and sign the informed consent form.
You're excluded if
- Those with neuropsychiatric disorders such as stroke, epilepsy, or schizophrenia;
- Those with cognitive impairment caused by depression, thyroid disease, traumatic brain injury, drug or alcohol intoxication;
- Those with a history of cerebrovascular disease or cognitive impairment caused by severe cardiac, hepatic, pulmonary, or renal impairment;
- Those who are complete vegetarians and are unable to comply with the balanced dietary pattern;
- Those who suffer from severe angina pectoris, asthmatic bronchitis, severe infections , systemic lupus erythematosus, malignant tumors, and other diseases that may affect one's dietary habits and life;
- Coeliac disease with lipid malabsorption.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-06-17