NCT06930742 · NOT YET RECRUITING
Mindfulness-Enhanced Dual-Task Training in PD-MCI
This trial is testing whether combining mindfulness training with dual-task training (doing a cognitive and physical task at the same time) improves thinking and movement in people who have both Parkinson's disease and mild cognitive impairment. Three groups are compared over four weeks. This is a Phase NA study, meaning it is an interventional trial focused on a specific therapeutic technique rather than a drug, and results are not yet established.
You may qualify if
- Age: Between 55 and 75 years.
- Disease Diagnosis: Clinically diagnosed with Idiopathic Parkinson's Disease (PD) according to the UK Parkinson's Disease Society Brain Bank Criteria.
- Disease Stage: Hoehn \& Yahr (H\&Y) stages 1 to 2.5.
- Cognitive Function: Montreal Cognitive Assessment (MoCA) score between 23 and 26, indicating mild cognitive impairment (MCI).
- Medication Stability: Stable doses of antiparkinsonian medications for at least 4 weeks prior to screening.
- Subjective Cognitive Complaints: Self-reported or informant-reported cognitive decline persisting for at least 6 months.
- Ambulatory Ability: Able to walk independently, with or without assistive devices.
- Sensory Abilities: Adequate vision and hearing to comply with study procedures.
- Informed Consent: Willingness to provide written informed consent and comply with study requirements.
You're excluded if
- Other Neurological Disorders: Presence of other neurological conditions that could affect cognitive function, such as Alzheimer's disease, stroke, or brain tumors.
- Psychiatric Conditions: Severe psychiatric disorders, including major depressive disorder or schizophrenia.
- Substance Abuse: Recent history of drug or alcohol abuse.
- Serious Medical Conditions: Uncontrolled hypertension, diabetes, heart disease, or other conditions that could interfere with study participation or outcomes.
- Severe Cognitive Impairment: Diagnosis of Parkinson's Disease Dementia (PDD).
- Other Factors Affecting Cognition: Recent head trauma, uncontrolled thyroid dysfunction, vitamin B12 deficiency, or other conditions known to affect cognitive function.
- Deep Brain Stimulation (DBS): History of DBS treatment. Participation in Other Clinical Trials: Participation in another clinical trial that could interfere with this study within the last 3 months.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-04-16