NCT06873750 · NOT YET RECRUITING
Neuromodulation and fMRI in Neurodegenerative Diseases Study
This trial is testing whether a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve working memory in people with mild cognitive impairment, neurodegeneration, or traumatic brain injury. It uses fMRI and EEG brain scans to see whether the stimulation actually changes how brain networks communicate. This is a Phase NA study, meaning it is exploratory research focused on understanding how the intervention works rather than proving it as a treatment.
Eligibility criteria
Inclusion Criteria: 1. Be at least 25 years of age; 2. Have no contraindications to MRI 3. Have received 8 or more years of formal education 4. Be fluent in English 5. Cohort a. must be followed at Sunnybrook Health Sciences Center Cohort a: * Have been diagnosed with a suspected neurodegenerative disorder or traumatic brain injury (TBI) with memory deficits impacting functional status * In case of TBI, cognitive impairment has persisted at least three months post-injury * Received score of 16 or lower on the Mini Mental State Examination (MMSE) Cohort b: * Have no prior diagnosis of a neurodegenerative disorder or post-traumatic brain injury cognitive deficits * Be experiencing healthy aging and be age and sex matched to Cohort a. Exclusion Criteria: 1. Have any contraindications to MRI 2. Be pregnancy 3. Have any major comorbid medical conditions (as determined by investigators - e.g., comorbid neurological diseases, uncontrolled hypertension or diabetes, malignancy) or major comorbid psychiatric conditions (as determined by investigators - e.g., schizophrenia or bipolar disorder)
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-05-01