NCT06755164 · ACTIVE NOT RECRUITING
Effects of Combined Aerobic and Cognitive Training in a Simultaneous or Sequential Paradigm on Cognition and Brain Functional Activity in Patients with AMCI
This trial tests two ways of combining aerobic exercise with cognitive training for people who already have amnestic mild cognitive impairment. One group does the activities back-to-back; the other does them at the same time. Researchers will measure cognitive changes and brain activity using neuropsychological tests and fMRI scans. This is a Phase NA randomized controlled trial — it is testing which method works better, not a drug, and it has not been proven superior to standard care yet.
You may qualify if
- a diagnosis of amnesic mild cognitive impairment according to the current diagnostic criteria;
- age>60 years;
- stable acetylcholinesterase inhibitors and/or memantine at the time of enrolment for at least one month;
- subscription of the consent for personal data treatment and patients' informed consent for participation in the present study.
You're excluded if
- patients with a history of other systemic, neurologic, psychiatric diseases, head injury, cardiovascular events, and cerebrovascular alterations visible at an MRI scan;
- patients with a family history of neurodegenerative disorders;
- patients with a history of alcohol and/or psychotropic drugs abuse;
- patients who are used to do regular physical and/or cognitive activity;
- contraindication to perform MRI scan (cardiac pace-maker or other types of cardiac catheters, splinters or metallic shards, metallic prosthesis not compatible with magnetic field generated by MRI, claustrophobia, pregnancy, breastfeeding).
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-01-10