NCT06746909 · RECRUITING
Identification of Neuroinflammation and Neuroimaging Biomarkers Through Data Driven Artificial Intelligence Techniques for Unraveling the Heterogeneity of Aged Subjects at Risk of Dementia and to Better Inform Prevention Strategies
This study is using AI and brain imaging to look for patterns in people with early memory concerns — either mild cognitive impairment (MCI) or subjective cognitive decline (SCD). Researchers will scan participants' brains, measure blood flow, and analyze immune system markers in the blood to find subgroups who may be at higher risk of progressing toward dementia. It also tests a combined cognitive and physical training program. This is a non-drug, observational and intervention study, not a treatment trial.
You may qualify if
- age between 65 and 89 years; 5 years of schooling;
- diagnosis of Mild Cognitive Impairment (Croisile et al., 2011) or
- diagnosis of Subjective Cognitive Decline (Jessen et al., 2014).
You're excluded if
- neurological pathologies; dementia;
- psychiatric disorders;
- pathologies or orthopedic problems limiting participation to the aerobic physical training program and to the MR imaging.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2024-12-24