NCT06668610 · RECRUITING
A Multifocal TDCS-EEG Protocol for Improving Symptoms of Mild Cognitive Impairment and Early Dementia
This trial is testing whether a non-invasive brain stimulation technique called multifocal tDCS, combined with cognitive training, can ease thinking and mood symptoms in people with mild cognitive impairment or early dementia. Half the participants get real stimulation, half get a placebo version that feels the same but delivers no current. It is a Phase NA study, meaning it is a controlled trial focused on measuring effectiveness rather than early safety testing.
You may qualify if
- age between 55 and 85 years;
- diagnosis of minor neurocognitive disorder, or major neurocognitive disorder with mild severity, according to Diagnostic and Statistical Manual of Mental Disorders (DSM-5; APA 2013) with a Clinical Dementia Rating Scale (CDR) of .05 or 1 (Morris, 1993);
- right handedness.
You're excluded if
- brain events with an acute aetiology (stroke, traumatic brain injury, neoplastic ablation);
- psychiatric disorders (schizophrenia, psychosis, bipolar disorder) and assumption of psychotropic drugs;
- diagnosis of moderate or severe major neurocognitive disorders (DSM-5; APA 2013) with CDR scores equal or above 2 (Morris, 1993);
- any condition with may also hypothetically interfere with electrophysiological recording and neurostimulation (metallic implants in the brain, cochlear implant, pacemakers, or suffering from epilepsy) (Antal et al., 2017; Bikson et al., 2016).
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2024-10-31