NCT06640673 · RECRUITING
Electrophysiological Signature of Mild Cognitive Impairment and Its Relationship with Parkinson's Disease: a High-density EEG Investigation
This study uses high-density EEG brain scans to look for electrical patterns in the brain that might distinguish Parkinson's disease patients who have mild cognitive impairment from those who do not. Researchers will also combine the EEG data with MRI scans to study brain network connectivity. It is an observational study with no phase designation, meaning it is exploratory research rather than a drug or treatment trial.
You may qualify if
- Upper score >24 MMSE or >15.5 Moca
- If taking medications, taking stable doses for at least 4 weeks prior to the inclusion visit - of anticholinesterase drugs (donepezil, memantine, rivastigmine, ...) or antidepressants (SSRIs, tricyclics, SNARI, ...) or Levodopa.
- Having signed the informed consent
You're excluded if
- Subjects with severe dementia ( MMSE \< 24 )
- Lower score \<15.5 Moca
- Subjects on antipsychotic treatment for less than 3 months
- Subjects with uncontrolled comorbidities
- Subjects with metal prostheses or dentures and in general conditions for which MRI examinations are prevented.
- Subjects with an inability to walk independently.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2024-10-15