NCT06608316 · RECRUITING
Intermittent Theta-burst Stimulation for Mild Cognitive Impairment
This trial is testing whether a non-invasive brain stimulation technique called intermittent theta-burst stimulation (iTBS) can improve thinking skills, balance, and walking ability in people with mild cognitive impairment (MCI). Researchers will also compare stimulating one side of the brain versus both sides. Phase NA here means this is likely a feasibility or pilot study — exploratory, not a late-stage proven treatment.
You may qualify if
- Aged≥65 years;
- Patient-reported subjective cognitive decline and the total score of the Hong Kong version of Montreal Cognitive Assessment (HK-MoCA) was between 19 and 25;
- Intact daily functioning in ADL scales and being independent in daily living, and ability to walk at least for 1 minute independently without an assistive device;
- No serious visual or hearing impairment and can complete relevant assessment and testing;
- Signed informed consent of patients and their families for iTBS treatment.
You're excluded if
- Identified with contraindications in the rTMS screening questionnaire;
- Cognitive dysfunction due to craniocerebral trauma or neurological diseases;
- Presence of severe physical illnesses such as speech disorders or unstable cardiac arrhythmias;
- Currently in a critical condition such as fever, infection, or organ failure;
- Significant damage to the left frontal lobe cortex;
- Currently taking antidepressants or psychostimulants;
- Unstable vital signs or organ failure;
- Neuropsychiatric comorbidity or affective disorder that could affect the test results;
- Patients with dementia.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-03-13