NCT06453980 · RECRUITING
Multimodal Investigation of Neural Plasticity
This trial tests whether transcranial direct current stimulation (tDCS) — a gentle, non-invasive electrical brain stimulation delivered through a headset — can influence brain function and memory. Participants with mild cognitive impairment (MCI) and healthy older adults receive either real stimulation or a sham (inactive) version. This is a Phase NA study, meaning it is exploratory research focused on understanding brain effects, not a late-stage treatment trial.
You may qualify if
- Normal cognition for HC and diagnosis of Mild Cognitive Impairment (MCI) for MCI participants
- Right-handedness
- Magnetic resonance compatible, criteria that also apply for high definition transcranial direct current stimulation (HD-tDCS; e.g., absence of metallic or electronic implants in the upper body or head)
You're excluded if
- History of other contributing neurological or medical conditions known to affect cognitive functioning
- Significant mental illness
- Sensory impairments that limit ability to participate
- History of alcohol or drug abuse/dependence
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-03-10