NCT06385951 · RECRUITING
Spatial Navigation for the Early Detection of Alzheimer's Disease.
This trial is testing whether a virtual reality navigation task can serve as an early detection tool for Alzheimer's disease. Participants wear a VR headset and complete spatial memory challenges while also undergoing brain scans, PET imaging, and spinal fluid analysis. Researchers want to see if how well someone navigates in virtual space correlates with early Alzheimer's brain changes. This is a Phase NA diagnostic study — it is evaluating a detection method, not a treatment.
You may qualify if
- Patients with a Mild Cognitive Impairment (MCI) due to Alzheimer's Disease (AD)
- Patients with a mild Alzheimer's Dementia
- Patients with MCI without a formal dementia diagnosis
- Healthy controls
You're excluded if
- Diabetes (only for healthy controls)
- Epilepsy
- Presence of extreme depressive symptoms (>11 on Geriatric depression scale or >20 on Beck depression inventory)
- Presence of extreme anxiety (>22 on Beck Anxiety Inventory)
- A major psychiatric of medical disorder
- Alcohol excess
- Moderate to severe white matter lesions on MRI (>2 Fazekas)
- Any visual of mobility impairment of such severity as to compromise the ability to undertake the iVR task.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2024-04-26