NCT06246929 · RECRUITING
Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline
This trial compares two behavioral programs for Black older adults who have both chronic pain and early signs of cognitive decline. One program combines mindfulness-based cognitive therapy with walking (MBCT+w); the other is an active-living exercise program (ALED). Researchers want to see which works better for physical, cognitive, and emotional wellbeing over six months. This is a Phase N/A trial — a head-to-head comparison of two existing approaches, not a drug test.
You may qualify if
- Black adults, male and females, age 50 or older
- Have nonmalignant musculoskeletal chronic pain for more than three months
- Reports early cognitive decline (subjective and objective)
- Telephone Interview for Cognitive Status-41 score greater than or equal to 31
- Functional Activities Questionnaire score less than 9
- English fluency/literacy
- Free of concurrent psychotropic or pain medication for at least 2 weeks prior to initiation of treatment, OR stable on current psychotropic or pain medication for a minimum of 6 weeks and willing to maintain stable dose
- Cleared by medical doctor for study participation and no self-reported concerns about physical functioning on the revised Physical Activity Readiness Questionnaire (PAR-Q; score 0)
You're excluded if
- Diagnosed with dementia or neurodegenerative disease
- Regular use of nonpharmacological pain management
- Diagnosed with serious mental illness or substance abuse
- Current suicidal ideation on self-report
- Engagement of regular exercise for more than 30 minutes daily
- Unable to walk
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-05-26