NCT06202872 · RECRUITING
Memory Enhancement Using Transcranial Alternating Current Stimulation
This trial is testing whether a wearable brain stimulation device called tACS, tuned to a 40 Hz frequency and aimed at a specific brain region called the precuneus, can improve memory in people with mild cognitive impairment linked to Alzheimer's. Researchers will use detailed brain scans to watch what happens during and after the stimulation. This is a Phase NA study, meaning it is primarily investigational and exploratory, not yet a proven therapy.
You may qualify if
- Recent (not more than 6 months ago) amnestic MCI diagnosis, which consensus is obtained in a multidisciplinary meeting after an extended multidisciplinary test battery at the memory clinic, including confirmation of AD pathology with cerebrospinal fluid biomarkers: abnormal p-tau/Aβ42 ratio of > 0.023
You're excluded if
- Suffering from serious neurological, psychiatric or somatic comorbidity
- Suffering from epileptic seizures or severe claustrophobia
- Intensive use of psychoactive medication
- Having a cardiac pacemaker, internal cardiac defibrillator or other intracorporeal device that interferes with MEG recordings
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2024-12-20