NCT06089096 · RECRUITING
Sleep Apnea and Cognitive Function in Subjects With Subjective or Mild Cognitive Impairment
This study is testing whether people with early memory concerns — either mild cognitive impairment or subjective cognitive complaints — also have undiagnosed obstructive sleep apnea. Participants wear a home sleep monitor to check for sleep apnea. It is an observational study, not a drug trial, meaning researchers are looking for a connection rather than testing a treatment. The goal is to understand whether sleep apnea is a contributing factor in early cognitive decline.
You may qualify if
- Aged 18 years and above
- Clinical diagnosis of mild cognitive impairment (MCI) based on Petersen's criteria. The criteria include the following: (1) memory problems, (2) objective memory disorder, (3) absence of other cognitive disorders or repercussions on daily life, (4) normal general cognitive function and (5) absence of dementia OR,
- Diagnosis of subjective cognitive impairment, based on the subject's own complaint of cognitive impairment but with an unremarkable assessment of the Hong Kong version of Montreal Cognitive Assessment scores
- Able to speak and read Chinese
- Adequate visual and auditory to perform a cognitive test
You're excluded if
- Diagnosed psychiatric illness with or without medication, e.g. major depressive disorder.
- Other clear organic causes of cognitive impairment, e.g. old stroke, brain tumour, dementia with Lewy body, Parkinson's disease, normal pressure hydrocephalus, neurosyphilis, autoimmune encephalitis, substance abuse, history of alcohol abuse.
- Diagnosis of major unstable illness or cancer on active treatment
- Unable to perform Home Sleep Apnea Test
- Those patients who require legal guardians
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-04-02