NCT06024473 · RECRUITING
A rTMS and Virtual Reality Based Cognitive Rehabilitation Program for MCI
This trial is testing whether combining brain stimulation (rTMS) with immersive virtual reality cognitive training improves thinking, mood, daily functioning, and quality of life in people already diagnosed with Mild Cognitive Impairment. Participants are assigned to no treatment, rTMS alone, or rTMS plus VR training over two weeks, then followed for three months. This is a Phase NA interventional study — it is evaluating effectiveness of a combined non-drug approach, not a standard drug trial.
You may qualify if
- age 55 and over
- previous diagnosis of Mild Cognitive Impairment
- Score of 18 or over on the MoCA during pre-screening procedures.
You're excluded if
- below 55 years old
- Do not pass the TMS Adult Safety Screening
- Taking medications known to increase risk of seizure
- Taking ototoxic medications
- Those with implanted device
- History of bipolar disorder
- History of Tourette's syndrome or presence of motor tics
- History of seizures/ seizures in first degree relatives
- History of stroke, aneurysm, or cranial neurosurgery
- Current alcohol related disorder needing medical treatment
- History of abnormal electroencephalogram (EEG)
- History of motion sickness, nausea, vomiting, seizures, or migraine
- Significant balance/gait impairments/history of falls
- History of hyperacusis or photophobia
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-02-20