NCT05968703 · RECRUITING
Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease
This trial is testing whether adding a second set of brain stimulation electrodes, targeting a memory-related brain region called the Nucleus Basalis of Meynert, is safe and tolerable alongside the standard deep brain stimulation surgery already used for Parkinson's motor symptoms. It is a Phase NA, meaning it is an early feasibility study focused on safety, not yet testing whether it works. Only ten participants are planned.
You may qualify if
- Diagnosis of Parkinson's disease (PD)
- Approved (or planning on) for subthalamic nucleus (STN) deep brain stimulation (DBS)
- Willingness to withdraw from clinical medication regimen when necessary for research visits
- Ability to provide informed consent
You're excluded if
- Dementia
- Unstable medical, psychiatric conditions including significant untreated depression, history of suicidal attempt, or current suicide ideation
- History of seizures
- Pregnant
- Requires MRI
- Unable to walk 100 feet without an assistive device
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-05-30