NCT05845918 · ACTIVE NOT RECRUITING
PRogram to Improve Stress-levels and Enhance Memory
This pilot study is testing a remote lifestyle program called PRISEM — combining health education, nutrition, physical activity, cognitive exercises, and stress reduction — in people with Mild Cognitive Impairment. Researchers want to see if it can lower chronic stress, improve vascular health, and sharpen executive function over 12 months. This is a Phase NA pilot study, meaning it is an early exploratory effort to see if the program is feasible and shows any signal worth pursuing further.
You may qualify if
- Age: 50 years or older
- Fluency in English
- African American or White
- MCI will be defined as subjective memory complaints with a Montreal Cognitive Assessment (MoCA) 19- 25
- Prior diagnosis of MCI
- Participants would be sedentary at baseline (self-report of \<30 minutes of structured physical activity \<3 times per week in the last 6 months) and have poor Mediterranean-Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay (MIND) diet scores (using the MIND diet screener)
You're excluded if
- Dementia diagnosis or reversible causes of dementia (e.g., if the patient has hypothyroidism or low vitamin B12 that is contributing to the subject's cognitive impairment)
- Active medical or psychiatric diseases that in the judgment of the investigator would affect the safety of the subject or scientific integrity of the study (e.g., actively manic patient)
- Uncontrolled medical conditions, such as congestive heart failure, reflected by poor exercise tolerance and shortness of breath
- Any physical ailment, such as stroke with residual impairment, that is a barrier to performing study procedures and attending sessions
- History of brain lesions, stroke, or major head trauma in the past year
- Those who are unable to demonstrate that they understood the details of the study (i.e., lack of decisional- capacity to consent) or linguistic limitations
- Pregnant women, prisoners, and adults unable to consent
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-11-06