NCT05785156 · RECRUITING
Diagnostic and Prognostic Value of New Quick Tests of Action Slowing in Stroke and in Cognitive Neurodegenerative Disease
This trial tests whether simple, quick assessments of how fast a person moves and reacts can help doctors diagnose neurodegenerative diseases earlier or predict how well stroke patients recover. Researchers will compare these speed tests against brain imaging to understand what brain changes drive slowing. There is no phase designation, meaning this is an observational diagnostic study rather than a drug or treatment trial.
Eligibility criteria
Inclusion Criteria: * Patients between 40 and 85 years old, * French native language, * Social Security affiliation. * University Memory Clinic for: Mild severity disorder (MMSE> 19) or major severity disorder related to AD : Albert 2011 criteria ; McKhann 2011 * to MCL according to McKeith criteria * to FTLD according to Rascovsky 2011 criteria * BBD according to Armstrong's criteria * related to PSP according to Höglinger criteria Exclusion Criteria: * Mental retardation or guardianship * Previously diagnosed dementia * Other current or past brain condition * severe head trauma * epilepsy prior to stroke still requiring previous treatment * Parkinson disease, multiple sclerosis... * brain tumor or brain radiation therapy * Current or past schizophrenia or psychosis * Active or past psychiatric disorders requiring a stay> 2 days in a specialized environment * Contra indication to MRI * Comorbidity with life expectancy \<1 year * Comorbidity affecting cognition in particular: * Alcohol (> 3 glasses / day) or history of alcohol withdrawal syndrome * opiate or cocaine addiction or opiate withdrawal syndrome * renal failure (dialysis or creatinine clearance \<30) * hepatic failure (spontaneous INR> 1.5 or PT \<60%) * respiratory failure requiring oxygen therapy * heart failure (orthopnea> 2 pillows) * persistent vigilance disturbances (NIHSS1a score ≤1) * cancer with paraneoplastic syndrome * treatment with gold salts, D Penicillamine or other treatment with cognitive effect * Patient under guardianship or curators or private under public law * Pregnant and / or lactating wom
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-05-13