NCT05771844 · RECRUITING
Home Sleep Therapy for Older Adults With MCI
This trial is testing a home-use device called SleepWISP that delivers gentle, non-invasive electrical stimulation to the brain during sleep. The goal is to see whether boosting deep sleep improves memory in people with mild cognitive impairment. It is a Phase NA study, meaning it sits outside the standard drug-approval pipeline — researchers are evaluating whether the device works and collecting data on Alzheimer's-related biomarkers through blood and nasal samples.
You may qualify if
- For participant with Amnestic MCI, the inclusion age range is 55-85 years old.
- For healthy volunteers without MCI, the inclusion age range is 40-80 years old.
You're excluded if
- History of seizures
- History of epilepsy
- History of mod/severe brain injury or trauma (including neurosurgery)
- History or presence of significant neurological disease such as Parkinson
- History of Electroconvulsive Therapy (ECT)
- Presence of severe insomnia
- Presence of untreated sleep apnea
- Presence of severe anxiety or depression
- Medications that may affect the EEG
- History of stroke
- Sensitivity or allergy to lidocaine or silver
- Presence of active suicidal ideation
- Presence of metal in head or implants or medication infusion device
- Pregnancy
- Adverse reaction to TMS
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-02-17