NCT05625425 · RECRUITING

Wayfinding Intervention and Long-Term Memory

This trial tests whether a VR-based navigation video game called LabyrinthVR can improve long-term memory and hippocampal function in older adults with or at risk for mild cognitive impairment. Participants play either the VR game or a placebo game and undergo brain imaging to measure changes. This is a Phase NA behavioral study, meaning it is testing a non-drug approach rather than a medication.

You may qualify if

  • fluent speakers of English
  • completed 12 or more years of education
  • normal or corrected-to-normal vision
  • dexterity to comfortably operate the scanner-compatible response box
  • freedom from physical and neurological conditions contra-indicated for fMRI
  • must confirm physical stamina and comfort for semi-weekly brisk 30-minute walks on level ground

You're excluded if

  • use of psychotropic medications
  • history of concussions or dizziness, vestibular or balance problems
  • significant discomfort with virtual reality experiences

The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.

Eligibility criteria as of 2024-12-18

View full record on ClinicalTrials.gov

All APOE4 clinical trials