NCT05460468 · RECRUITING
Neuromodulation of Memory in Aging
This trial is testing whether a non-invasive brain stimulation technique called closed-loop TMS can improve working memory in healthy older adults and people with mild cognitive impairment. TMS uses magnetic pulses aimed at a specific brain network in the prefrontal cortex. It is a Phase NA study, meaning it is exploratory research focused on understanding how the technique works, not a late-stage test of a proven treatment.
You may qualify if
- English Speaking
- Willing to provide consent
You're excluded if
- History of any Axis I DSM-V disorder, excluding major depressive disorder or generalized anxiety disorders
- Current history of substance abuse or dependence (excluding nicotine)
- Intracranial implants (e.g. aneurysms clips, shunts, stimulators, cochlear implants, or electrodes), cardiac pacemakers, or vagus Nerve stimulation device
- Increased risk of seizure for any reason, including prior diagnosis of epilepsy, seizure disorder, increased intracranial pressure, or history of significant head trauma with loss of consciousness for ≥ 5 minutes.
- Neurological disorder including, but not limited to: space occupying brain lesion; any history of seizures, history of cerebrovascular accident; fainting, cerebral aneurysm, Dementia, Hungtington chorea; Multiple Sclerosis.
- Current use of medications known to lower the seizure threshold and/or affect working memory
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-10-14