NCT05460143 · RECRUITING
Optical Neuroimaging and Cognition
This study is testing whether near-infrared spectroscopy, a light-based brain scan, can detect changes in brain oxygen use and metabolism in people with Alzheimer's disease, Lewy body dementia, or mild cognitive impairment. Researchers also want to see if machine learning can identify optical markers of dementia. No phase is listed because this is an observational study, not a drug trial. Details on size and timeline are limited.
Eligibility criteria
Inclusion Criteria: 1. A diagnosis of probable: * Lewy Body Dementia * Alzheimer's Disease * Mild Cognitive Impairment (MCI-LB or MCI-AD) OR 2. Cognitively normal for their education and age, with a MMSE score above 26 AND * A good grasp of the English language * An informant (either a carer or family member) who will be available throughout testing (only relevant if in a patient group) Exclusion Criteria: 1. Severe dementia * Unable to participate * A MMSE score below 12 2. A condition which influences metabolism or haemodynamics * Such as metabolic or respiratory disorders 3. A significant mental illness * Such as rheumatoid arthritis, systemic lupus erythematosus * Oral steroid use 4. A significant psychiatric disorder 5. MCI due to other causes such as traumatic brain injury, vascular dementia, or fronto-temporal dementia 6. A history of excessive drug or alcohol use 7. Contraindications to MRI (only for patient groups undertaking the MRI scan: AD/MCI/DLB) * Surgical implants e.g. pacemakers * Obesity
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-04-10