NCT05446584 · Phase 2 · RECRUITING
Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History
This trial is testing whether a history of mild traumatic brain injury (concussion) plays a role in the biological changes seen in amnestic mild cognitive impairment. The tool being used is HD-tDCS, a non-invasive brain stimulation device that delivers a weak electrical current through the scalp. Researchers will also analyze blood biomarkers. This is a Phase 2 study, meaning it is exploring how something works, not proving a treatment is effective.
You may qualify if
- Active diagnosis of amnestic mild cognitive impairment
- Presence of an mTBI history for the mTBI+ group; absence of an mTBI history for a control sample
- Female and male subjects
- All races/ethnicities
- Age 55 years and older
- Fluent in English
You're excluded if
- Mild traumatic brain injury within past year
- Lifetime history of moderate or severe brain injury
- Lifetime major neurologic syndromes (e.g., stroke, epilepsy, brain tumor)
- Lifetime major cardiovascular conditions (e.g., heart attack, heart failure)
- Current substance use disorder
- Current major psychiatric disorders (e.g., major depressive disorder, bipolar disorder)
- Current vision or hearing impairment that interferes with testing
- Any electronic and or metallic implants in the skull or brain
- Current medication use known to alter HD-tDCS reactivity
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-05-04