NCT05372172 · RECRUITING
Tennessee Alzheimer's Project
The Tennessee Alzheimer's Project is a long-term observational study based at Vanderbilt University. Researchers are building a detailed registry of up to 1,000 people — some cognitively healthy, some with mild cognitive impairment, some with Alzheimer's — tracking them annually with clinical assessments, biosamples, and brain imaging. This is not a treatment trial. The data collected will be shared to support other Alzheimer's research across the country.
You may qualify if
- Age 60 or older
- Meet standard criteria for (a) cognitively unimpaired, (b) mild cognitive impairment, or (c) Alzheimer's disease
- English speaking
- Individuals who lack decisional capacity to provide informed consent at baseline will not be enrolled in the study
You're excluded if
- No available reliable study partner (reliable is defined as someone who interacts significantly with the participant and is available to participate in study visits in person or by phone)
- History of major psychiatric illness (e.g., schizophrenia, bipolar), neurological illness (e.g., epilepsy, multiple sclerosis, Parkinson's disease), or head injury with significant loss of consciousness.
- Unable to undergo MRI (e.g., claustrophobia, ferrous metal in body)
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-02-05