NCT04792528 · ACTIVE NOT RECRUITING
REACT MCI - Repeated Advanced Cognitive Training in Mild Cognitive Impairment
This trial is testing whether computerized working memory training helps people with mild cognitive impairment (MCI) think more clearly and function better in daily life. Participants in Norway are randomly assigned to two rounds of training, one round, or an active control. Researchers will also measure brain clearance, genetics, and caregiver stress over four years. This is a Phase NA study — meaning it is evaluating a behavioral intervention rather than a drug.
Eligibility criteria
Inclusion Criteria for the REACT MCI study: * Diagnosis of MCI, based on the Mayo/winblad criteria or confirmation of current MCI status within the last 6 months before study enrollment. * The ability to use and accessibility to an iPad or computer. * Fluent in Norwegian. * Spinal tap performed and results available Exclusion Criteria for the REACT MCI study: * Patients unable to undergo a MRI investigation based on claustrophobia or metal foreign bodies are excluded from the study. * Major psychiatric illness and current substance abuse * Recent stroke Inclusion Criteria for the REACT MCI Glymphatics substudy: * Enrollment in the REACT MCI study * Participant allocated to Sorlandet Hospital or Oslo University Hospital Exclusion Criteria for the REACT MCI Glymphatics substudy: * Individuals with known allergy against contrast solutions * Individuals with other serious allergies * Individuals with kidney failure or glomerular filtration rate \< 30 * Individuals younger than 18 or older than 80 * Pregnant or lactating women * For individuals >70 years or with medications affecting kidney function the glomerular filtration rate needs to be less than week old.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-04-30