NCT04566900 · ACTIVE NOT RECRUITING
Neurofeedback to Improve Working Memory in Mild Cognitive Impairment
This trial is testing whether neurofeedback — a technique that trains people to consciously shift their own brain activity using real-time visual or audio feedback — can improve working memory in people with mild cognitive impairment. Researchers are focusing on boosting gamma wave activity in the frontal brain. It is a Phase NA designation, meaning this is a smaller foundational study designed to build evidence for larger trials down the road, not a proven treatment.
You may qualify if
- Meet criteria for mild cognitive impairment (MCI).
- Living independently.
- Literate in English.
- Competent to participate in the informed consent process and provide voluntary informed consent.
You're excluded if
- Frontal temporal dementia
- Active alcohol or substance use disorder within the past year.
- Brain cancer
- Stroke within the last 2 years
- Anti-epileptic medication
- Prior head injury involving loss of consciousness
- Seizure disorder
- Use of medications likely to affect cognitive function (cf. donepezil, memantine). We will not exclude for other medications but will examine their effects and include medications as covariates as appropriate (e.g., presence v. absence; anticholinergic load).
- The potential benefits of the study do not outweigh the potential risks of the study, as determined by the PI.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-01-27