Breathing, Relaxation, Attention Training, & Health in Older Adults (BREATHE)

Eligibility criteria

Inclusion Criteria:
1. All participants will require a diagnosis of "mild cognitive impairment due to Alzheimer's disease"using the most recent NIA and Alzheimer's Association workshop criteria:
   1. Presence of memory complaint,
   2. Rey Auditory Verbal Learning Test delayed recall (for memory) \< 6,
   3. Montreal Cognitive Assessment (for global cognition) ranged 18 and 25,
   4. Activities of Daily Living Questionnaire ≤ 30,
2. Intact score for San Diego Brief Assessment of Capacity to Consent (UBACC).
3. If a participant is on Alzheimer's disease medication (i.e., memantine or cholinesterase inhibitors), antidepressants, anxiolytics, or vascular risk or diseases related medications (e.g., beta- blocker), the dose should be stable for 3 months prior to recruitment.
4. Age 60-89,
5. English-speaking,
6. Adequate visual and hearing acuity for using mobile-based apps and testing by self-report, and
7. Community-dwelling.
Exclusion Criteria:
1. Current enrollment in another cognitive improvement study;
2. Uncontrollable symptoms of major depression;
3. Major cerebrovascular and cardiovascular diseases (e.g., congestive heart failure, pacemaker, prior myocardial infarction);
4. Neurological diseases (e.g., Parkinson's disease, Multiple Sclerosis);
5. Having an active legal guardian (indicating impaired capacity for decision making);
6. MRI contraindication (e.g., pacemaker, claustrophobia).
7. Color blindedness
8. Alcohol dependency in the past 5 years that are the main contributor to MCI

The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.

Eligibility criteria as of 2025-07-09