NCT04474379 · ACTIVE NOT RECRUITING
Everyday Memory Impairment in PD-related Cognitive Decline
This trial is testing a behavioral strategy-training program designed to help people with Parkinson's disease manage everyday memory problems. Participants are randomly assigned to either strategy training or a process-training comparison. Researchers then track memory performance over 12 months. This is a Phase N/A trial, meaning it is a behavioral intervention study rather than a drug trial — it is not testing whether a treatment is safe or effective in the pharmaceutical sense.
You may qualify if
- Males and females over age 50 who meet criteria for typical idiopathic PD
- Hoehn \& Yahr stage I-III,
- Treated with levodopa/carbidopa
- Have subjective memory complaints (as identified in phone screen),
- Have an informant to complete relevant ratings,
- Medications should be stable for 4 weeks prior with no changes planned during the treatment portion of the study (Pre to Post); changes over the follow-up period will be tracked and accounted for as appropriate.
You're excluded if
- Dementia according to MDS criteria or MoCA score \<21.
- Other neurological disorders (e.g. stroke, seizures), brain surgery, severe systemic diseases, major psychiatric disorder or history of psychotic symptoms (e.g. schizophrenia, bipolar disorder, delusions, hallucinations), or drug abuse.
- Treatment with medications that interfere with cognition (e.g. anticholinergics).
- Any other condition that would interfere with participation (e.g., non-English speaking, significant current depression).
- Psychiatric conditions/ symptoms that are common in PD (e.g. anxiety, depression) are allowed if they are deemed insufficient to interfere with participation.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-03-18