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Our Scientific Board, Phoenix Experiment, Partnerships and more!

April has been 🔥🔥🔥

T
· Reviewed by Dr. Kevin Tran, PharmD

Key takeaways · TL;DR

Phoenix welcomed Dr. Yadong Huang of UCSF Gladstone Institute to its Scientific Advisory Board, advanced the Phoenix Experiment as the first N-of-Many trial network for APOE4 carriers, and secured 20 percent off whole genome sequencing at Sequencing.com using code THEPHOENIX. April also featured rich community discussions on rapamycin, Alpha GPC, psyllium husk, and CGM glucose tracking.

Definition

A group of APOE4 and Alzheimer researchers who advise Phoenix on protocols, experiments, and evidence standards.

Dr. Yadong Huang of UCSF Gladstone Institute joined the board to advise the Phoenix Experiment N-of-Many trial network.

Definition

A concept for choosing foods with a favorable satisfaction to metabolic damage ratio, supporting long-term APOE4 protocol adherence.

Tactical indulgence allows occasional high-satisfaction foods selected for minimal impact on lipids, glucose, and inflammation.

Hi Friends,

April was a big one for us — both in science and in community momentum.

We’re now doubling our subscribers every month, and I just wanted to take a moment to thank you all for being here.

Whether you’re quietly reading or actively engaging, your presence fuels everything we’re building.

The Phoenix Community newsletter active subscribers doubling every month!

🧠 Dr. Yadong Huang joins our Scientific Board

We’re thrilled to welcome Dr. Yadong Huang to our Scientific Advisory Board. He’s a globally recognized leader in ApoE and Alzheimer’s research, known for pioneering work on ApoE4-targeted therapies at the Gladstone Institutes and UCSF. His presence adds major firepower to our mission.

He’ll be directly advising us on the Phoenix Experiment—our most ambitious project to date.

Speaking of which..

🔬 Progress on The Phoenix Experiment

This is the world’s first continuous, community-driven, N-of-Many trial network for ApoE4 carriers—designed to discover, personalize, and optimize your best possible protocol to beat the odds and defeat Alzheimer’s.

Instead of waiting years for traditional clinical trials, we’re creating a system that learns in real-time what’s best for each individual.

Your wearables, biomarkers, scans and lifestyle data get matched with others like you (same genes, environment, habits, preferences), so we can detect what really works—faster, smarter, and without the noise.

Structured. Personalized. Peer-powered. And built with you, not just for you.

🧬 New Partner: Whole Genome Sequencing at Sequencing.com – 20% Off for Members and Newsletter readers

Sequencing.com is a platform that offers advanced genetic testing, including whole genome sequencing, and tools to help you interpret your DNA for health, longevity, and disease prevention.
We’ve secured 20% off which is the best deal they offer.
How? Instead of an affiliate commission, we asked them to pass the savings entirely to you so we can always stay 100% unbiased and give you the best deals.

Use code: THEPHOENIX during checkout for 20% Off

Dr. Brandon Colby, the founder of Sequencing.com and author of Outsmart your Genes will also be joining us soon for a live Q&A!

More partnerships coming soon!

🌱 What We Explored in The Phoenix Community this Month:

Join the discussion by applying to The Phoenix—mention you're a newsletter reader to access more insights and exclusive member perks.

Supplements, Nutrition, and medication

  • Coconut oil

  • Saturated Fat

  • Psyllium husk - For fiber and tactical use to blunt absorption of glucose / saturated fat

  • Is Alcohol good or bad for you? In moderation or not at all?

  • How do you track your Nutrition? Macros, saturated fat, fiber etc?

  • Dairy fat, Cheese, Cream.. Are they all equally bad for LDL-C?

  • Rapamycin

  • Experience with fasting (intermittent and multi-day)

  • Cholesterol medication?

  • Recipe share

  • Cure for Alzheimer's?

  • "Tactical indulgence": foods with a good "satisfaction-to-damage" ratio

  • Choline (Alpha GPC), big "no regret" supplement

  • Question on MCT oil

  • Coenzyme Q10 (Ubiquinol)

  • LPC-DHA (Lysoveta)

Sports, Sleep, and Stress management

  • What sports / activities do you do ?

  • Ways to reduce stress

  • When I found out I had APOE4/4, my brain played tricks on me

Biomarkers, Tracking, Monitoring

  • Homocysteine

  • I'm seeing a lot of DETAILED information....

Toxins, Pathogens, Heavy metals

  • Plasma exchange / blood donation

Tech and Medical devices

  • Red Light Therapy

Genetics

  • BDNF Gene Question

Research

  • Studies with sampling bias

  • AD/PD™ 2025 International Conference on Alzheimer’s and Parkinson’s Diseases

  • Interesting study on suvorexant for sleep possibly helping with prevention

  • Not all clinical studies are equal

  • Alzheimer's Association International Conference - Advancements: APOE & Lipid Biology - March 2025

Open journal

  • CGM and getting control of glucose

  • Mediterranean Keto + Fasting (intermittent / multi days)

As always, thank you for being part of this mission to explore the science—and build real solutions—for ApoE4.


We’re just getting started. 🧡

—Kevin

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FAQ

Frequently asked questions.

Who is Dr. Yadong Huang and why did he join Phoenix?
Dr. Yadong Huang is a globally recognized leader in APOE and Alzheimer disease research based at the Gladstone Institutes and UCSF, known for pioneering work on APOE4-targeted therapies. He joined the Phoenix Scientific Advisory Board to directly advise the Phoenix Experiment, the community most ambitious research project. His involvement adds scientific rigor and credibility to the N-of-Many trial network while keeping recommendations actionable for APOE4 carriers. Huang laboratory has developed APOE4 structure correctors and other candidate interventions that may eventually be tested through Phoenix community-driven trials.
How do Phoenix members get 20 percent off Sequencing.com whole genome sequencing?
Phoenix negotiated a 20 percent discount at Sequencing.com, which founder Dr. Kevin Tran describes as the best deal the platform offers. Rather than taking an affiliate commission, Phoenix asked Sequencing.com to pass the entire savings directly to members and newsletter readers so the recommendation stays unbiased. Use code THEPHOENIX at checkout to apply the discount. Sequencing.com founder Dr. Brandon Colby, author of Outsmart Your Genes, also joined Phoenix for a live Q&A on whole genome sequencing for APOE4 carriers.
What supplements and nutrition topics did Phoenix discuss in April?
April discussions covered rapamycin protocols, Alpha GPC as a no-regret choline supplement, LPC-DHA (Lysoveta) phospholipid omega-3, Coenzyme Q10 (ubiquinol), MCT oil, psyllium husk for fiber and glucose blunting, and cholesterol medications including statins. Members debated coconut oil and saturated fat, how to track macros and fiber, alcohol in moderation versus abstinence, and intermittent and multi-day fasting. The tactical indulgence concept emerged for foods with a high satisfaction to metabolic damage ratio, helping APOE4 carriers stay adherent to long-term protocols without feeling deprived.
What is the Phoenix Experiment N-of-Many trial network?
The Phoenix Experiment is the first continuous, community-driven N-of-Many trial network built exclusively for APOE4 carriers. It matches each members wearable data, biomarkers, brain scans, and lifestyle inputs with peers who share similar genetics, environment, and habits to detect what actually works without the noise of averaged population data. Instead of waiting years for traditional trials, Phoenix generates real-time evidence, adapting protocols as new data arrives. The system is structured, personalized, peer-powered, and built with members rather than simply for them.
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