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We Found Your Brain Health Missing Link

Phoenix is partnering with NeuroAge!

T
· Reviewed by Dr. Kevin Tran, PharmD

Key takeaways · TL;DR

Phoenix is partnering with NeuroAge, built by MIT-trained physician-neuroscientist Dr. Christin Glorioso, to give APOE4 carriers a single brain-age score from four assessments: RNA blood panel, 3D brain MRI, cognitive gaming, and 300+ gene panel. Glorioso's research shows APOE4 carriers who are biologically 5 years younger in brain age have Alzheimer's risk below the general population average, completely canceling the genetic disadvantage.

Definition

A biological measurement of how young or old your brain is compared to your chronological age, based on neurological and molecular biomarkers.

Brain age captures the actual state of your neural tissue and function rather than just the years you have been alive. It combines structural imaging, blood biomarkers, cognitive performance, and genetic context into a single metric. For APOE4 carriers, brain age is particularly valuable because it measures the outcome that matters (neural health) rather than just the risk factor (genotype). Interventions that improve brain age should, over time, translate into reduced dementia risk, making it a better tracking metric than lipid panels alone.

Hi Phoenix friend,

You've been tracking your supplements. Logging your check-ins. Watching your biomarkers trend.

But there's always been a question in the back of your mind:

Is any of this actually moving the needle on brain aging?

Today we're answering that question.

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Introducing NeuroAge

Phoenix is partnering with NeuroAge — a company built by Dr. Christin Glorioso, MIT-trained physician-neuroscientist and APOE4 carrier herself.

Psst: we have negotiated a special discount code for our members: use the code PHOENIX during checkout at NeuroAge for -20%!

NeuroAge gives you a single number: how many years younger (or older) your brain is compared to your chronological age.

It combines four assessments:

- RNA blood panel (52 biomarkers) — captures what's actually happening in your neurons, from your blood

- Brain MRI with 3D mapping — tracks hippocampal volume, white matter health, and brain shrinkage rates over time

- Cognitive gaming — reaction time, memory, processing speed versus people your same age

- Genetic panel (300+ genes) — because APOE4 is only ~30% of your genetic Alzheimer's risk

The result: a NeuroAge score that tells you exactly where your brain stands — and whether what you're doing is working.

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Why This Matters for APOE4 Carriers

Dr. Glorioso's research (20 years, MIT) found something important:

APOE4 carriers who were biologically 5 years younger in brain age had Alzheimer's risk below the general population average — completely canceling out the genetic disadvantage.

The opposite is also true. Carriers who skew older are at significantly elevated risk.

Brain aging is separate from your genetics. That means it's changeable. And now it's measurable.

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How Phoenix + NeuroAge Work Together

Think of it this way:

> NeuroAge tells you where your brain is. Phoenix shows you what to do about it.

Your NeuroAge score flows into the Phoenix Health Hub as a baseline. From there, you can:

- Track which supplements, habits, and interventions correlate with your brain age score

- See how your wearables and daily check-ins connect to cognitive outcomes

- Measure progress between NeuroAge retests

- Join pods with members optimizing for the same goals

- Get matched to clinical trials relevant to your profile

This is measurement + action + community. In one place.

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Join NeuroAge with the code PHOENIX (to add during checkout) and get a 20% discount on your NeuroAge plan.

A Note on Integration

We're actively building a deep integration between NeuroAge and the Phoenix platform: so your brain age flows seamlessly into your Health Hub alongside your bloodwork, wearables, and check-ins.

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NeuroAge provides health information, not medical diagnosis. Discuss results with your healthcare provider.

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FAQ

Frequently asked questions.

What is NeuroAge and how does it measure brain age?
NeuroAge is a brain-age assessment built by Dr. Christin Glorioso, an MIT-trained physician-neuroscientist who is also an APOE4 carrier. It produces a single number telling you how many years younger or older your brain is compared to your chronological age. The score combines four assessments: an RNA blood panel measuring 52 biomarkers that capture what's actually happening in your neurons, a brain MRI with 3D mapping that tracks hippocampal volume and white matter health over time, cognitive gaming that tests reaction time, memory, and processing speed versus same-age peers, and a 300+ gene panel because APOE4 is only about 30 percent of your genetic Alzheimer's risk. Phoenix members get 20 percent off with code PHOENIX.
Can APOE4 carriers cancel out their genetic Alzheimer's risk?
According to Dr. Christin Glorioso's 20 years of MIT research, yes. APOE4 carriers who were biologically 5 years younger in brain age had Alzheimer's risk BELOW the general population average, completely canceling out the genetic disadvantage. The opposite is also true: carriers whose brain age skewed older showed significantly elevated risk. The key insight is that brain aging is separate from your genetics, meaning it's modifiable through lifestyle interventions and now measurable through tools like NeuroAge. This reframes APOE4 from a fixed destiny into a high-leverage starting point where small improvements in brain aging produce disproportionate risk reduction.
Is APOE4 the only genetic Alzheimer's risk factor?
No. APOE4 accounts for approximately 30 percent of your total genetic Alzheimer's risk, which means roughly 70 percent comes from other genes. This is why NeuroAge includes a 300+ gene panel rather than just testing APOE. Other genes involved in lipid metabolism, neuroinflammation, amyloid clearance, and synaptic function all contribute to overall risk. For APOE4 carriers, knowing your full genetic picture helps prioritize which interventions will have the biggest impact. Two APOE4 carriers with identical APOE status can have very different total genetic risk based on these other genes, which means personalized protocols matter.
What are the four components of a NeuroAge assessment?
NeuroAge combines four assessments to produce a single brain-age score. First, an RNA blood panel measuring 52 biomarkers captures what is actively happening in your neurons from a blood draw. Second, a brain MRI with 3D mapping tracks hippocampal volume, white matter health, and brain shrinkage rates over time. Third, cognitive gaming measures reaction time, memory, and processing speed benchmarked against people your same age. Fourth, a 300+ gene panel provides the genetic context beyond just APOE4. The four streams combine into one actionable number that you can track across retests to see whether your interventions are actually slowing brain aging.
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