NCT07650188 · RECRUITING
Stimulating the Aging Brain Using Brain and Sensory Stimulation
This trial is testing two non-drug brain stimulation techniques in people with primary progressive aphasia, a condition that erodes language ability. One technique uses gentle electrical current applied to the scalp (tACS); the other uses combined sensory input. Researchers want to know whether either approach improves verbal short-term memory. This is a Phase NA study, meaning it is exploratory research focused on feasibility and early signal, not a proven or approved treatment.
You may qualify if
- Clinical exam supports diagnosis of PPA and/or MCI with no report of difficulty functioning in basic or instrumental activities of daily living.
- Completed clinical cognitive exam within 6 months of study baseline visit OR neuropsychological research battery within 6 months of study baseline visit.
You're excluded if
- Evidence of dementia at baseline
- Known history of neoplasm, symptomatic stroke, moderate to severe traumatic brain injury, or other significant neurologic event
- Age \<45 years.
- Evidence of severe psychiatric illness (e.g., bipolar disorder, schizophrenia).
- Presence of cardiac stimulators or pacemakers
- Any other implants near the scalp or in the eye
- Contraindications to MRI or stimulation
- Pregnancy
- History of ongoing or unmanaged seizures
- History of dyslexia or other developmental learning disabilities
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-06-16