BCI With 40Hz Stimulation in Alzheimer's Disease

You may qualify if

• Diagnosis of Alzheimer's disease according to the NIA-AA 2018 diagnostic criteria.
• Age between 50 and 80 years, inclusive.
• Positive Aβ-PET scan result.
• Has a stable caregiver who can assist with daily stimulation intervention.
• Chronic medical conditions stable for at least 30 days.
• Adequate vision and hearing to perform testing (at minimum, ability to perceive light and communicate in daily conversation).
• Good mobility (able to walk independently or with assistive devices).
• Willing and able to provide voluntary signed informed consent.

You're excluded if

• History of epilepsy or seizure disorder.
• Inability to undergo MRI or presence of significant abnormalities on MRI screening.
• Geriatric Depression Scale (GDS) score > 6.
• Current suicidal ideation or suicide attempt within the past 6 months.
• Other major neurological disorders, including but not limited to: dementia with Lewy bodies, frontotemporal dementia, Huntington's disease, Creutzfeldt-Jakob disease, Down syndrome, or mixed dementia; other neurodegenerative diseases (Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, etc.); history of severe brain infection (meningitis/encephalitis) or multiple concussions; metabolic/systemic diseases causing cognitive impairment (syphilis, vitamin B12 or folate deficiency, etc.).
• Psychiatric disorders.
• Severe cardiac disease, chronic liver/kidney/respiratory disease, or uncontrolled diabetes mellitus or thyroid disease.
• History of drug or alcohol abuse within the past 12 months.
• Current exposure to anti-Aβ antibody immunotherapies.
• Current use of memantine within 30 days prior to intervention.
• Life expectancy \< 24 months.

The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.

Eligibility criteria as of 2026-06-01