NCT07608640 · NOT YET RECRUITING
Management of Age-Related Auditory Decline and Early Warning of Its Co-occurring Dementia
This observational study is tracking more than 3,000 older adults in China to explore the link between age-related hearing loss and cognitive decline. Researchers will collect hearing tests, cognitive assessments, and blood samples, then use AI to build predictive tools — including something called a Hearing Health Clock — for earlier detection of dementia risk. No phase is listed because no drug or device is being tested; this is a data-gathering and model-building study.
Eligibility criteria
Inclusion Criteria: 1. Aged 60 years or older. 2. Clear consciousness and able to cooperate with all study assessments and examinations. 3. Permanent local residents who have lived in the area for at least 9 months per year and are willing to complete long-term follow-up. long-term follow-up： 1. Diagnosis of sensorineural hearing loss. 2. Bilaterally symmetric hearing with air conduction threshold difference ≤15 dB at 0.5 kHz, 1 kHz, 2 kHz and 4 kHz between two ears. 3. Hearing loss not caused by non-age-related factors. Exclusion Criteria: 1. Unable to complete pure-tone audiometry and other auditory examinations. History of central nervous system diseases, including Parkinson's disease, stroke, intracranial tumor or brain trauma. 2. Severe uncontrolled systemic diseases (cardiac, pulmonary, hepatic, renal insufficiency) or advanced malignant tumor with expected survival less than 3 years. 3. Any other condition judged by the investigator inappropriate for study enrollment.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-05-27